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Tramadol hydrochloride

Item number	673118
CAS	22204-88-2
Formula	C16H26ClNO2
Molecular weight	299,80 g/mol
Quantity	1X100MG
storage conditions	4 °C
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Tramadol hydrochloride		673118 22204-88-2	1X100MG	Please log in.

Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 20.11.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	Tramadol hydrochloride
Catalog No.:	673118
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H336 Long-term (chronic) aquatic hazard (Category 2), H411
Label elements
Pictogram	GHS06 skull skull GHS09 Aquatic-pollut-red Aquatic-pollut-red
	2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Signal Word Danger Hazard statement(s) H301 Toxic if swallowed. H336 May cause drowsiness or dizziness. H411 Toxic to aquatic life with long lasting effects. Precautionary statement(s) P261 Avoid breathing dust. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Supplemental Hazard Statements none Reduced Labeling (<= 125 ml) Signal Word Danger Hazard statement(s) H301 Toxic if swallowed. Precautionary statement(s) P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : (±)-cis-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol hydrochloride Component: trans-(±)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol hydrochloride CAS-No. : 36282-47-0 EC-No. : 252-950-2 Classification: Acute Tox. 3; STOT SE 3; Aquatic Chronic 2; H301, H336, H411 Concentration: <= 100 %
Formula	C16H26ClNO2
Molecular Weight (g/mol)	299.80
CAS-No.	22204-88-2
FIRST AID MEASURES	4.1 Description of first-aid measures General advice Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. Call in physician. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. In case of eye contact After eye contact: rinse out with plenty of water. Remove contact lenses. If swallowed If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Water Foam Carbon dioxide (CO2) Dry powder Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Hydrogen chloride gas Combustible. Development of hazardous combustion gases or vapours possible in the event of fire. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. 6.4 Reference to other sections For disposal see section 13
HANDLING AND STORAGE	7.1 Precautions for safe handling Advice on safe handling Work under hood. Do not inhale substance/mixture. Hygiene measures Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. Storage class Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION	8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Body Protection protective clothing Respiratory protection required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains.
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Physical state powder b) Color white c) Odor No data available d) Melting point/freezing point Melting point/range: 178 - 181 °C e) Initial boiling point and boiling range No data available f) Flammability (solid, gas) No data available g) Upper/lower flammability or explosive limits No data available h) Flash point No data available i) Autoignition temperature No data available j) Decomposition temperature No data available k) pH 5,0 - 6,0 at 10 g/l at 20 °C l) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available m) Water solubility soluble n) Partition coefficient: n-octanol/water No data available o) Vapor pressure No data available p) Density 0,400 - 0,600 g/cm3 Relative density No data available q) Relative vapor density No data available r) Particle characteristics No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information No data available
STABILITY AND REACTIVITY	10.1 Reactivity The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid no information available 10.5 Incompatible materials Strong oxidizing agents 10.6 Hazardous decomposition products In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 228 mg/kg Acute toxicity estimate Oral - 228 mg/kg (Calculation method) Inhalation: No data available LD50 Dermal - Rabbit - > 500 mg/kg Skin corrosion/irritation Skin - Rabbit Result: No skin irritation Serious eye damage/eye irritation Eyes - Rabbit Result: Mild eye irritation Respiratory or skin sensitization No data available Germ cell mutagenicity No data available Carcinogenicity No data available Reproductive toxicity No data available Specific target organ toxicity - single exposure May cause drowsiness or dizziness. Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
ECOLOGICAL INFORMATION	12.1 Toxicity Toxicity to fish LC50 - Leuciscus idus (Golden orfe) - 6,2 mg/l - 96,0 h Toxicity to bacteria 12.2 Persistence and degradability Biodegradability Result: < 5 % - Not readily biodegradable. (Closed Bottle test) Remarks: Taking into consideration the properties of several ingredients, the product is estimated not to be readily biodegradable according to OECD classification. 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. 12.7 Other adverse effects No data available
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods No data available
TRANSPORT INFORMATION	14.1 UN number ADR/RID: 2811 IMDG: 2811 IATA: 2811 14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (trans-(±)-2-[(Dimethylamino)methyl]-1-(3- methoxyphenyl)cyclohexan-1-ol hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (trans-(±)-2-[(Dimethylamino)methyl]-1-(3- methoxyphenyl)cyclohexan-1-ol hydrochloride) IATA: Toxic solid, organic, n.o.s. (trans-(±)-2-[(Dimethylamino)methyl]-1-(3- methoxyphenyl)cyclohexan-1-ol hydrochloride) 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards ADR/RID: yes IMDG Marine pollutant: yes IATA: no 14.6 Special precautions for user No data available
REGULATORY INFORMATION	15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. National legislation Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ACUTE TOXIC : ENVIRONMENTAL HAZARDS Other regulations Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!