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2-Methyl-4-isothiazoline-3-one

Item number675700
CAS2682-20-4
FormulaC4H5NOS
Molecular weight115,15 g/mol
Quantity 1X100MG
storage conditions4 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
2-Methyl-4-isothiazoline-3-one

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2-Methyl-4-isothiazoline-3-one

2-Methyl-4-isothiazoline-3-one

675700
2682-20-4

1X100MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:2-Methyl-4-isothiazoline-3-one
Catalog No.:675700
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 3), H331
Skin corrosion (Category 1B), H314
Skin sensitisation (Category 1), H317
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Acute aquatic toxicity (Category 1), H400 Classification according to EU Directives 67/548/EEC or 1999/45/EC
T, Xi,
N
Toxic, Irritant, Dangerous for
the environment
R22, R23, R34, R43, R50
Label elements
PictogramGHS05 acid
acid
GHS06 skull
skull
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Danger Hazard statement(s)
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
H331 Toxic if inhaled.
H335 May cause respiratory irritation.
H400 Very toxic to aquatic life.
Precautionary statement(s)
P261 Avoid breathing dust.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Synonyms : 2-Methyl-3(2H)-isothiazolone
Formula : C4H5NOS
Molecular weight : 115,15 g/mol
CAS-No. : 2682-20-4
EC-No. : 220-239-6
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
2-Methyl-2H-isothiazol-3-one
CAS-No.
EC-No.
2682-20-4
220-239-6
Acute Tox. 4; Acute Tox. 3;
Skin Corr. 1B; Skin Sens. 1;
STOT SE 3; Aquatic Acute 1;
H302, H314, H317, H331,
H335, H400
<= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
2-Methyl-2H-isothiazol-3-one
CAS-No.
EC-No.
2682-20-4
220-239-6
T, N, R22 - R23 - R34 - R37 -
R43 - R50
<= 100 %
FormulaC4H5NOS
Molecular Weight (g/mol)115.15
CAS-No.2682-20-4
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take
victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Sulphur oxides
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Air sensitive. Store under inert gas.
7.3 Specific end uses
no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: Powder with lumps
Colour: white
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing
point
Melting point/range: 48 - 50 °C
f) Initial boiling point and
boiling range
93 °C at 0,04 hPa
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower
flammability or
explosive limits
No data available
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: noctanol/
water
log Pow: 0,119
p) Auto-ignition
temperature
No data available
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available
STABILITY AND REACTIVITY10.1 Reactivity
no data available
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
no data available
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Other decomposition products - no data available
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitisation
Germ cell mutagenicity
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: NX8157080
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of
the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is
extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin.
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 0,07 mg/l - 96,0 h
Toxicity to daphnia and
other aquatic
invertebrates
Immobilization EC50 - Daphnia magna (Water flea) - 0,18 mg/l - 48 h
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
no data available
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
no data available
12.6 Other adverse effects
Very toxic to aquatic life.
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 3261 IMDG: 3261 IATA: 3261
14.2 UN proper shipping name
ADR/RID: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (2-Methyl-2H-isothiazol-3-one)
IMDG: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (2-Methyl-2H-isothiazol-3-one)
IATA: Corrosive solid, acidic, organic, n.o.s. (2-Methyl-2H-isothiazol-3-one)
14.3 Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
14.6 Special precautions for user
no data available
REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
15.2 Chemical Safety Assessment
no data available
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!