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Indomethacin
| Item number | 674586 |
| CAS | 53-86-1 |
| Formula | C19H16ClNO4 |
| Molecular weight | 357,79 g/mol |
| Quantity | 1X250MG |
| storage conditions | 20 °C |
| CoA / MSDS | Retrieve CoA Retrieve MSDS |
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Product Variations:
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 674586 | 1X250MG | Please log in. | |
Indomethacin solution |  | 680921 | 1X10ML | Please log in. |
Indomethacin solution |  | 686287 | 1X1ML | Please log in. |
| Safety Data Sheet | according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 14.11.2024 |
| IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING | |
| Product name: | Indomethacin |
| Catalog No.: | 674586 |
| Relevant identified uses of the substance or mixture | Identified: Laboratory chemical uses: R&D |
| Uses advised against: | HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com |
| Emergency telephone number | HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours. |
| HAZARDS IDENTIFICATION | 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 1), H300 Classification according to EU Directives 67/548/EEC or 1999/45/EC T+ Very toxic R28 |
| Label elements | |
| Pictogram | GHS06 skull skull |
| Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H300 Fatal if swallowed. Precautionary statement(s) P264 Wash hands thoroughly after handling. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Supplemental Hazard Statements none 2.3 Other hazards - none | |
| COMPOSITION/INFORMATION ON INGREDIENTS | 3.1 Substances Synonyms : 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid Formula : C19H16ClNO4 Molecular Weight : 357,79 g/mol CAS-No. : 53-86-1 EC-No. : 200-186-5 Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration Indometacin CAS-No. EC-No. 53-86-1 200-186-5 Acute Tox. 1; H300 <= 100 % Hazardous ingredients according to Directive 1999/45/EC Component Classification Concentration Indometacin CAS-No. EC-No. 53-86-1 200-186-5 T+, R28 <= 100 % |
| Formula | C19H16ClNO4 |
| Molecular Weight (g/mol) | 357.79 |
| CAS-No. | 53-86-1 |
| FIRST AID MEASURES | 4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed no data available |
| FIRE-FIGHTING MEASURES | 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide 5.2 Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas 5.3 Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. 5.4 Further information no data available |
| ACCIDENTAL RELEASE MEASURES | 6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13 |
| HANDLING AND STORAGE | 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| EXPOSURE CONTROLS/PERSONAL PROTECTION | 8.1 Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains |
| PHYSICAL AND CHEMICAL PROPERTIES | 9.1 Information on basic physical and chemical properties a) Appearance Form: powder Colour: beige b) Odour no data available c) Odour Threshold no data available d) pH no data available e) Melting point/freezing point 155 °C f) Initial boiling point and boiling range no data available g) Flash point no data available h) Evapouration rate no data available i) Flammability (solid, gas) no data available j) Upper/lower flammability or explosive limits no data available k) Vapour pressure no data available l) Vapour density no data available m) Relative density no data available n) Water solubility no data available o) Partition coefficient: noctanol/ water no data available p) Auto-ignition temperature no data available q) Decomposition temperature no data available r) Viscosity no data available s) Explosive properties no data available t) Oxidizing properties no data available 9.2 Other safety information no data available |
| STABILITY AND REACTIVITY | 10.1 Reactivity no data available 10.2 Chemical stability Light. Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions no data available 10.4 Conditions to avoid no data available 10.5 Incompatible materials Strong bases 10.6 Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 |
| TOXICOLOGICAL INFORMATION | 11.1 Information on toxicological effects Acute toxicity LD50 Oral - rat - 2,42 mg/kg Remarks: Gastrointestinal:Ulceration or bleeding from stomach. Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation no data available Germ cell mutagenicity rat Other cell types Host-mediated assay rat Dominant lethal test Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity Laboratory experiments have shown teratogenic effects. Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: NL3500000 Liver - Irregularities - Based on Human Evidence |
| ECOLOGICAL INFORMATION | 12.1 Toxicity no data available 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available 12.4 Mobility in soil no data available 12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted 12.6 Other adverse effects no data available |
| DISPOSAL CONSIDERATIONS | 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. |
| TRANSPORT INFORMATION | 14.1 UN number ADR/RID: 2811 IMDG: 2811 IATA: 2811 14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Indometacin) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Indometacin) IATA: Toxic solid, organic, n.o.s. (Indometacin) 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: I IMDG: I IATA: I 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user no data available |
| REGULATORY INFORMATION | This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out |
| OTHER INFORMATION | The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only! |