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beta-Estradiol hemihydrate Solution (Solvent: Methanol)

Item number	677783
CAS	35380-71-3
Formula	C18H24O2 x 0.5 H2O
Molecular weight	281,31 g/mol
Quantity	1X1ML
Concentration	100 µg/ml
Solvent	Methanol
storage conditions	20 °C
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Product		Catalog No./ CAS No.	Quantity	Price
beta-Estradiol hemihydrate solution Concentration: 100 µg/ml Solvent: Methanol		677783 35380-71-3	1X1ML	Please log in.

Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 25.11.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	beta-Estradiol hemihydrate
Catalog No.:	677783
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Specific target organ toxicity - single exposure (Category 1), H370 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC F Highly flammable R11 T Toxic R23/24/25, R39/23/24/25
Label elements
Pictogram	flamme flamme GHS06 skull skull GHS08 silhouete silhouete
	Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H370 Causes damage to organs. Precautionary statement(s) P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P311 Call a POISON CENTER or doctor/ physician. Supplemental Hazard Statements none 2.3 Other hazards This substance is not considered to be persistent, bioaccumulating nor toxic (PBT)., This substance is not considered to be very persistent nor very bioaccumulating (vPvB).
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : Methyl alcohol Formula : CH4O Molecular Weight : 32,04 g/mol CAS-No. : 67-56-1 EC-No. : 200-659-6 Index-No. : 603-001-00-X Registration number : 01-2119433307-44-XXXX Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration Methanol CAS-No. EC-No. Index-No. Registration number 67-56-1 200-659-6 603-001-00-X 01-2119433307-44-XXXX Flam. Liq. 2; Acute Tox. 3; STOT SE 1; H225, H301 + H311 + H331, H370 <= 100 % Hazardous ingredients according to Directive 1999/45/EC Component Classification Concentration Methanol CAS-No. EC-No. Index-No. Registration number 67-56-1 200-659-6 603-001-00-X 01-2119433307-44-XXXX F, T, R11 - R23/24/25 - R39/23/24/25 <= 100 %
Formula	C18H24O2 x 0.5 H2O
Molecular Weight (g/mol)	281.31
CAS-No.	35380-71-3
FIRST AID MEASURES	4.1 Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed no data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides 5.3 Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. 5.4 Further information Use water spray to cool unopened containers.
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). 6.4 Reference to other sections For disposal see section 13.
HANDLING AND STORAGE	7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. 7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C 7.3 Specific end use(s) no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION	8.1 Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Appearance Form: liquid Colour: colourless b) Odour pungent c) Odour Threshold no data available d) pH no data available e) Melting point/freezing point Melting point/range: -98 °C f) Initial boiling point and boiling range 64,7 °C g) Flash point 9,7 °C - closed cup h) Evapouration rate no data available i) Flammability (solid, gas) no data available j) Upper/lower flammability or explosive limits Upper explosion limit: 36 %(V) Lower explosion limit: 6 %(V) k) Vapour pressure 130,3 hPa at 20,0 °C 546,6 hPa at 50,0 °C 169,27 hPa at 25,0 °C l) Vapour density 1,11 m) Relative density 0,791 g/mL at 25 °C n) Water solubility completely miscible o) Partition coefficient: noctanol/ water log Pow: -0,77 p) Auto-ignition temperature 455,0 °C at 1.013 hPa q) Decomposition temperature no data available r) Viscosity no data available s) Explosive properties Not explosive t) Oxidizing properties The substance or mixture is not classified as oxidizing. 9.2 Other safety information Minimum ignition energy 0,14 mJ Conductivity < 1 µS/cm Relative vapour density 1,11
STABILITY AND REACTIVITY	10.1 Reactivity no data available 10.2 Chemical stability no data available 10.3 Possibility of hazardous reactions no data available 10.4 Conditions to avoid Heat, flames and sparks. Extremes of temperature and direct sunlight. 10.5 Incompatible materials Acids, Oxidizing agents, Alkali metals, Acid chlorides, Acid anhydrides, Reducing agents 10.6 Hazardous decomposition products Other decomposition products - no data available
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LDLO Oral - Human - 143 mg/kg Remarks: Lungs, Thorax, or Respiration:Dyspnea. Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea. LD50 Oral - rat - 1.187 - 2.769 mg/kg LC50 Inhalation - rat - 4 h - 128,2 mg/l LC50 Inhalation - rat - 6 h - 87,6 mg/l LD50 Dermal - rabbit - 17.100 mg/kg Skin corrosion/irritation Skin - rabbit Result: No skin irritation Serious eye damage/eye irritation Eyes - rabbit Result: No eye irritation Respiratory or skin sensitisation Maximisation Test - guinea pig Does not cause skin sensitisation. (OECD Test Guideline 406) Germ cell mutagenicity Ames test S. typhimurium Result: negative in vitro assay fibroblast Result: negative Mutation in mammalian somatic cells. Mutagenicity (in vivo mammalian bone-marrow cytogenetic test, chromosomal analysis) mouse - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity Damage to fetus not classifiable Fertility classification not possible from current data. Specific target organ toxicity - single exposure Causes damage to organs. Specific target organ toxicity - repeated exposure The substance or mixture is not classified as specific target organ toxicant, repeated exposure. Aspiration hazard No aspiration toxicity classification Additional Information RTECS: PC1400000 Methyl alcohol may be fatal or cause blindness if swallowed. Effects due to ingestion may include:, Headache, Dizziness, Drowsiness, metabolic acidosis, Coma, Seizures. Symptoms may be delayed., Damage of the:, Liver, Kidney
ECOLOGICAL INFORMATION	12.1 Toxicity no data available 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available 12.4 Mobility in soil no data available 12.5 Results of PBT and vPvB assessment no data available 12.6 Other adverse effects no data available
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods Product Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product.
TRANSPORT INFORMATION	14.1 UN number ADR/RID: 1230 IMDG: 1230 IATA: 1230 14.2 UN proper shipping name ADR/RID: METHANOL IMDG: METHANOL IATA: Methanol 14.3 Transport hazard class(es) ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1) 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG Marine Pollutant: no IATA: no 14.6 Special precautions for user no data available
REGULATORY INFORMATION	This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available 15.2 Chemical Safety Assessment no data available
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!