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Cycloheximide
| Item number | 684711 |
| CAS | 66-81-9 |
| Formula | C15H23NO4 |
| Molecular weight | 281,35 g/mol |
| Quantity | 1X100MG |
| storage conditions | 4 °C |
| CoA / MSDS | Retrieve CoA Retrieve MSDS |
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Product Variations:
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 684711 | 1X100MG | Please log in. | |
Cycloheximide solution |  | 688391 | 1X1ML |
| Safety Data Sheet | according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 15.01.2025 |
| IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING | |
| Product name: | Cycloheximide |
| Catalog No.: | 684711 |
| Relevant identified uses of the substance or mixture | Identified: Laboratory chemical uses: R&D |
| Uses advised against: | HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com |
| Emergency telephone number | HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours. |
| HAZARDS IDENTIFICATION | 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 2), H300 Germ cell mutagenicity (Category 2), H341 Reproductive toxicity (Category 1B), H360D Long-term (chronic) aquatic hazard (Category 2), H411 For the full text of the H-Statements mentioned in this Section, see Section 16. |
| Label elements | |
| Pictogram | GHS06 skull skull GHS08 silhouete silhouete GHS09 Aquatic-pollut-red Aquatic-pollut-red |
| 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H300 Fatal if swallowed. H341 Suspected of causing genetic defects. H360D May damage the unborn child. H411 Toxic to aquatic life with long lasting effects. Precautionary statement(s) P201 Obtain special instructions before use. P273 Avoid release to the environment. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Rinse mouth. Supplemental Hazard Statements none Restricted to professional users. Reduced Labeling (<= 125 ml) Pictogram Signal word Danger Hazard statement(s) H341 Suspected of causing genetic defects. H300 Fatal if swallowed. H360D May damage the unborn child. Precautionary statement(s) P201 Obtain special instructions before use. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Rinse mouth. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. | |
| COMPOSITION/INFORMATION ON INGREDIENTS | 3.1 Substances Synonyms : Actidione Naramycin A 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2- hydroxyethyl]glutarimide Formula : C15H23NO4 Molecular weight : 281,35 g/mol CAS-No. : 66-81-9 EC-No. : 200-636-0 Index-No. : 613-140-00-8 Component Cycloheximide CAS-No.66-81-9 EC-No.200-636-0 Index-No.613-140-00-8 Classification Acute Tox. 2; Muta. 2;Repr. 1B; Aquatic Chronic 2; H300, H341, H360D,H411 Concentration <= 100 % For the full text of the H-Statements mentioned in this Section, see Section 16. |
| Formula | C15H23NO4 |
| Molecular Weight (g/mol) | 281.35 |
| CAS-No. | 66-81-9 |
| FIRST AID MEASURES | 4.1 Description of first-aid measures General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available |
| FIRE-FIGHTING MEASURES | 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available |
| ACCIDENTAL RELEASE MEASURES | 6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13. |
| HANDLING AND STORAGE | 7.1 Precautions for safe handling Advice on safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Advice on safe handling Avoid exposure - obtain special instructions before use. Advice on protection against fire and explosion Provide appropriate exhaust ventilation at places where dust is formed. Hygiene measures Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Keep container tightly closed in a dry and well-ventilated place. Store in cool place. Storage class Storage class (TRGS 510): 6.1B: Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| EXPOSURE CONTROLS/PERSONAL PROTECTION | 8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a fullface particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU)Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. |
| PHYSICAL AND CHEMICAL PROPERTIES | 9.1 Information on basic physical and chemical properties a) Appearance Form: powder Color: beige b) Odor No data available c) Odor Threshold No data available d) pH No data available e) Melting point/freezing point Melting point/range: 110 - 118 °C f) Initial boiling point and boiling range No data available g) Flash point No data available h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower flammability or explosive limits No data available k) Vapor pressure No data available l) Vapor density No data available m) Density No data available Relative density No data available n) Water solubility slightly soluble o) Partition coefficient: n-octanol/water log Pow: 0,55 p) Autoignition temperature No data available q) Decomposition temperature No data available r) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information No data available |
| STABILITY AND REACTIVITY | 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Bases, Strong oxidizing agents, Acid anhydrides, Acid chlorides 10.6 Hazardous decomposition products In the event of fire: see section 5 |
| TOXICOLOGICAL INFORMATION | 11.1 Information on toxicological effects Acute toxicity Oral: No data available Inhalation: No data available Dermal: No data available Skin corrosion/irritation No data available Serious eye damage/eye irritation No data available Respiratory or skin sensitization Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. Germ cell mutagenicity Suspected of causing genetic defects. Carcinogenicity No data available Reproductive toxicity May damage the unborn child. Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information RTECS: MA4375000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.Liver - Irregularities - Based on Human Evidence |
| ECOLOGICAL INFORMATION | 12.1 Toxicity No data available 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects Toxic to aquatic life with long lasting effects. |
| DISPOSAL CONSIDERATIONS | 13.1 Waste treatment methods Product Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. Contaminated packaging Dispose of as unused product. |
| TRANSPORT INFORMATION | 14.1 UN number ADR/RID: 2811 IMDG: 2811 IATA: 2811 14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Cycloheximide) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Cycloheximide) IATA: Toxic solid, organic, n.o.s. (Cycloheximide) 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: yes IMDG Marine pollutant: yes IATA: no 14.6 Special precautions for user No data available |
| REGULATORY INFORMATION | 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. Authorisations and/or restrictions on use REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, preparations and articles (Annex XVII) : Cycloheximide National legislation Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ACUTE TOXIC : ENVIRONMENTAL HAZARDS : ACUTE TOXIC : ENVIRONMENTAL HAZARDS 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out |
| OTHER INFORMATION | The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only! |