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2-Chloroacetophenone

Item number	682272
CAS	532-27-4
Formula	C8H7ClO
Molecular weight	154,59 g/mol
Quantity	1X1000MG
storage conditions	20 °C
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2-Chloroacetophenone		682272 532-27-4	1X1000MG	Please log in.

Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 13.11.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	2-Chloroacetophenone
Catalog No.:	682272
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 2), H300 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318 Respiratory sensitization (Category 1), H334 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Label elements
Pictogram	GHS05 acid acid GHS06 skull skull GHS08 silhouete silhouete
	2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Signal Word Danger Hazard statement(s) H300 Fatal if swallowed. H311 + H331 Toxic in contact with skin or if inhaled. H315 Causes skin irritation. H318 Causes serious eye damage. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/ doctor if you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements none Reduced Labeling (<= 125 ml) Signal Word Danger Hazard statement(s) H300 Fatal if swallowed. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H318 Causes serious eye damage. H311 + H331 Toxic in contact with skin or if inhaled. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/ doctor if you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : ω-Chloroacetophenone Phenacyl chloride Formula : C8H7ClO Molecular weight : 154,59 g/mol CAS-No. : 532-27-4 EC-No. : 208-531-1 Component: 2-Chloroacetophenone Classification: Acute Tox. 2; Acute Tox. 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1; STOT SE 3; H300, H331, H311, H315, H318, H334, H335 Concentration: <= 100 %
Formula	C8H7ClO
Molecular Weight (g/mol)	154.59
CAS-No.	532-27-4
FIRST AID MEASURES	4.1 Description of first-aid measures General advice First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately. In case of eye contact After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses. If swallowed If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Water Foam Carbon dioxide (CO2) Dry powder Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Carbon oxides Hydrogen chloride gas Combustible. Development of hazardous combustion gases or vapours possible in the event of fire. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. 6.4 Reference to other sections For disposal see section 13.
HANDLING AND STORAGE	7.1 Precautions for safe handling Advice on safe handling Work under hood. Do not inhale substance/mixture. Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. Store under inert gas. Storage class Storage class (TRGS 510): 6.1A: Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION	8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles Skin protection This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. Body Protection protective clothing Respiratory protection required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains.
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Physical state crystalline b) Color beige c) Odor No data available d) Melting point/freezing point Melting point/range: 54 - 56 °C e) Initial boiling point and boiling range 244 - 245 °C f) Flammability (solid, gas) No data available g) Upper/lower flammability or explosive limits No data available h) Flash point No data available i) Autoignition temperature No data available j) Decomposition temperature No data available k) pH No data available l) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available m) Water solubility No data available n) Partition coefficient: n-octanol/water log Pow: 1,651 o) Vapor pressure 0,09 hPa at 50 °C p) Density 1,324 g/mL at 25 °C Relative density No data available q) Relative vapor density No data available r) Particle characteristics No data available s) Explosive properties No data available t) Oxidizing properties none 9.2 Other safety information No data available
STABILITY AND REACTIVITY	10.1 Reactivity The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid no information available 10.5 Incompatible materials Bases, Amines, Alcohols 10.6 Hazardous decomposition products In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 50 mg/kg LCLO Inhalation - Human - 20 h - 159 mg/m3 LD50 Dermal - 300 mg/kg LD50 Intravenous - Rabbit - 30 mg/kg Remarks: Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Respiratory stimulation. Kidney, Ureter, Bladder:Other changes. LD50 Intraperitoneal - Rat - 36 mg/kg Remarks: Behavioral:Coma. Lungs, Thorax, or Respiration:Other changes. Skin and Appendages: Other: Hair. LD50 Intraperitoneal - Guinea pig - 17 mg/kg Remarks: Behavioral:Coma. Lungs, Thorax, or Respiration:Other changes. Skin and Appendages: Other: Hair. LD50 Intraperitoneal - Mouse - 60 mg/kg LD50 Intravenous - Rat - 41 mg/kg Remarks: Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Respiratory stimulation. Kidney, Ureter, Bladder:Other changes. LD50 Intravenous - Mouse - 81 mg/kg Remarks: Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Respiratory stimulation. Kidney, Ureter, Bladder:Other changes. Skin corrosion/irritation Skin - Rat Result: Open irritation test - 6 h Serious eye damage/eye irritation Eyes - Rabbit Result: Severe eye irritation Remarks: Severe eye irritation Respiratory or skin sensitization May cause sensitization by inhalation and skin contact. Germ cell mutagenicity Test Type: Rat Test system: Liver Remarks: DNA damage Test Type: Hamster Test system: ovary Remarks: Cytogenetic analysis Carcinogenicity No data available Reproductive toxicity No data available Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation. Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. RTECS: AM6300000 Cough, Shortness of breath, Headache, Nausea, Vomiting To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
ECOLOGICAL INFORMATION	12.1 Toxicity Toxicity to fish LC50 - Lepomis cyanellus - 1,05 mg/l - 48 h 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. 12.7 Other adverse effects No data available
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods Product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
TRANSPORT INFORMATION	14.1 UN number ADR/RID: 1697 IMDG: 1697 IATA: 1697 14.2 UN proper shipping name ADR/RID: CHLOROACETOPHENONE, SOLID IMDG: CHLOROACETOPHENONE, SOLID IATA: Chloroacetophenone, solid Passenger Aircraft: Not permitted for transport 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user Tunnel restriction code : (D/E) Further information : No data available
REGULATORY INFORMATION	15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. National legislation Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ACUTE TOXIC Other regulations Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!