Celecoxib

Item number	688537
CAS	169590-42-5
Formula	C17H14F3N3O2S
Molecular weight	381,37 g/mol
Quantity	1X100MG
storage conditions	4 °C
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Celecoxib		688537 169590-42-5	1X100MG	Please log in.

Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	Celecoxib
Catalog No.:	688537
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Reproductive toxicity (Category 1B), H360D Specific target organ toxicity - repeated exposure (Category 2), H373 Long-term (chronic) aquatic hazard (Category 1), H410
Label elements
Pictogram	GHS08 silhouete silhouete GHS09 Aquatic-pollut-red Aquatic-pollut-red
	2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H360D May damage the unborn child. H373 May cause damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements none Reduced Labeling (<= 125 ml) Pictogram Signal word Danger Hazard statement(s) H360D May damage the unborn child. Precautionary statement(s) P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : Celecoxib Formula : C17H14F3N3O2S Molecular weight : 381,37 g/mol CAS-No. : 169590-42-5 EC-No. : 685-962-5 Component Classification Concentration 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide CAS-No. EC-No. 169590-42-5 685-962-5 Repr. 1B; STOT RE 2; Aquatic Chronic 1; H360D, H373, H410 M-Factor - Aquatic Chronic: 1 <= 100 %
Formula	C17H14F3N3O2S
Molecular Weight (g/mol)	381.37
CAS-No.	169590-42-5
FIRST AID MEASURES	4.1 Description of first-aid measures General advice Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. Call in physician. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician. In case of eye contact After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. If swallowed After swallowing: immediately make victim drink water (two glasses at most). Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Water Foam Carbon dioxide (CO2) Dry powder Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Sulfur oxides Hydrogen fluoride Combustible. Development of hazardous combustion gases or vapours possible in the event of fire 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. 6.4 Reference to other sections For disposal see section 13
HANDLING AND STORAGE	7.1 Precautions for safe handling Advice on safe handling Work under hood. Do not inhale substance/mixture. Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION	8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Skin protection This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L Body Protection protective clothing Respiratory protection required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Appearance Form: solid Color: White b) Odor No data available c) Odor Threshold No data available d) pH No data available e) Melting point/freezing point Melting point/range: 157 - 159 °C f) Initial boiling point and boiling range No data available g) Flash point Not applicable h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower flammability or explosive limits No data available k) Vapor pressure No data available l) Vapor density 13,17 - (Air = 1.0) m) Relative density No data available n) Water solubility No data available o) Partition coefficient: n-octanol/water No data available p) Autoignition temperature No data available q) Decomposition temperature No data available r) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Relative vapor density 13,17 - (Air = 1.0)
STABILITY AND REACTIVITY	10.1 Reactivity The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid no information available 10.5 Incompatible materials Strong oxidizing agents 10.6 Hazardous decomposition products In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - > 2.000 mg/kg Remarks: (External MSDS) Skin corrosion/irritation Skin - Rabbit Result: No skin irritation Remarks: (External MSDS) Serious eye damage/eye irritation No data available Respiratory or skin sensitization Maximization Test - Guinea pig Result: negative Remarks: (External MSDS) Germ cell mutagenicity No data available Carcinogenicity IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity May damage the unborn child. Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure May cause damage to organs through prolonged or repeated exposure. Aspiration hazard No data available 11.2 Additional Information RTECS: DB2944937 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated
ECOLOGICAL INFORMATION	12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - > 1,2 mg/l - 96 h Remarks: (External MSDS) Toxicity to daphnia and other aquatic invertebrates NOEC - Daphnia magna (Water flea) - 0,06 mg/l - 21 Days Remarks: (External MSDS) 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects No data available
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods Product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
TRANSPORT INFORMATION	14.1 UN number ADR/RID: 3077 IMDG: 3077 IATA: 3077 14.2 UN proper shipping name ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (4-[5-(4- Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (4-[5-(4- Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) IATA: Environmentally hazardous substance, solid, n.o.s. (4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) 14.3 Transport hazard class(es) ADR/RID: 9 IMDG: 9 IATA: 9 14.4 Packaging group ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards ADR/RID: yes IMDG Marine pollutant: yes IATA: yes 14.6 Special precautions for user Further information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
REGULATORY INFORMATION	15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, preparations and articles (Annex XVII) : Not applicable National legislation Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ENVIRONMENTAL HAZARDS Other regulations Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!

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Celecoxib