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Candesartan cilexetil

Item number689664
CAS145040-37-5
FormulaC33H34N6O6
Molecular weight610,66 g/mol
Quantity 1X100MG
storage conditions4 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
Candesartan cilexetil

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Candesartan cilexetil

Candesartan cilexetil

689664
145040-37-5

1X100MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Candesartan cilexetil
Catalog No.:689664
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Reproductive toxicity (Category 2), H361
Acute aquatic toxicity (Category 1), H400
Label elements
PictogramGHS08 silhouete
silhouete
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Warning
Hazard statement(s)
H361 Suspected of damaging fertility or the unborn child.
H400 Very toxic to aquatic life.
Precautionary statement(s)
P273 Avoid release to the environment.
P281 Use personal protective equipment as required. Supplemental Hazard
Statements
none
2.3 Other hazards - none
COMPOSITION/INFORMATION ON INGREDIENTSChemical name Candesartan Cilexetil 145040-37-5
Weight-% 100
REACH registrationnumber : -
EC No : -
Classification according toRegulation (EC) No.1272/2008 [CLP] Repr. 1A (H360D)Lact. (H362)STOT RE 2 (H373)Aquatic Acute 1(H400)Aquatic Chronic 1(H410)
Specific concentration limit (SCL)
M-Factor (long-term
Full text of H- and EUH-phrases: see section 16
Acute Toxicity Estimate
No information available
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.
1907/2006 (REACH), Article 59)
Spezifischer Konzentrationsgrenzwert(SCL)
M-Faktor
M-Faktor (langfristig)
Wortlaut der H- und EUH-Sätze siehe unter Abschnitt 16
Schätzung der akuten Toxizität
Es liegen keine Informationen vor
Dieses Produkt enthält keine besonders besorgniserregende Stoffe (SVHC) der Kandidatenliste in einer Konzentration von >=0,1%
(Verordnung (EG) Nr. 1907/2006 (REACH), Artikel 59)

FormulaC33H34N6O6
Molecular Weight (g/mol)610.66
CAS-No.145040-37-5
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary 5.4 Further information
No data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature 2 - 8 °C
Storage class (TRGS 510): Combustible solids, toxic
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: Crystalline powder
Colour: white
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing
point
Melting point/freezing point: 325.4 °C
f) Initial boiling point and
boiling range
No data available
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower
flammability or
explosive limits
No data available
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility practically insoluble
o) Partition coefficient: noctanol/
water
log Pow: > 3
p) Auto-ignition
temperature
No data available
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions 10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Oxidizing agents, Strong acids and strong bases
10.6 Hazardous decomposition products
Other decomposition products - No data available
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
No data availableCandesartan cilexetil
Inhalation: No data available(Candesartan cilexetil)
Dermal: No data available(Candesartan cilexetil)
LD50 Intraperitoneal - Rat - 940 mg/kg(Candesartan cilexetil)
Remarks: Behavioral:Somnolence (general depressed activity). Behavioral:Muscle weakness. Respiratory
disorder
LD50 Intraperitoneal - Mouse - 807 mg/kg(Candesartan cilexetil)
Skin corrosion/irritation
No data available(Candesartan cilexetil)
Serious eye damage/eye irritation
No data available(Candesartan cilexetil)
Respiratory or skin sensitisation
No data available(Candesartan cilexetil)
Germ cell mutagenicity
No data available(Candesartan cilexetil)
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Suspected human reproductive toxicant(Candesartan cilexetil)
No data available(Candesartan cilexetil)
Specific target organ toxicity - single exposure
No data available(Candesartan cilexetil)
Specific target organ toxicity - repeated exposure
Inhalation, Ingestion - May cause damage to organs through prolonged or repeated exposure. - Kidney,
Heart, Blood
Aspiration hazard
No data available(Candesartan cilexetil) Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.(Candesartan cilexetil)
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish EC50 - Oncorhynchus mykiss (rainbow trout) - > 0.017 mg/l - 96
h(Candesartan cilexetil)
Toxicity to daphnia and
other aquatic
invertebrates
EC50 - Daphnia magna (Water flea) - > 0.016 mg/l - 48 h(Candesartan
cilexetil)
Toxicity to algae EC50 - Algae - > 0.012 mg/l - 72 h(Candesartan cilexetil)
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available(Candesartan cilexetil)
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects
Very toxic to aquatic life.
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chem scrubber.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 3077 IMDG: 3077 IATA: 3077
14.2 UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Candesartan cilexetil)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Candesartan cilexetil)
IATA: Environmentally hazardous substance, solid, n.o.s. (Candesartan cilexetil)
14.3 Transport hazard class(es)
ADR/RID: 9 IMDG: 9 IATA: 9
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: no IATA: yes
14.6 Special precautions for user
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination
packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!