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Bupivacaine hydrochloride

Item number683869
CAS18010-40-7
FormulaC18H29ClN2O
Molecular weight324,89 g/mol
Quantity 1X100MG
storage conditions4 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
Bupivacaine hydrochloride

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Bupivacaine hydrochloride

Bupivacaine hydrochloride

683869
18010-40-7

1X100MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Bupivacaine hydrochloride
Catalog No.:683869
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1. Classification of the substance or mixture
Regulation (EC) No 1272/2008
Acute toxicity - Oral Category 2 - (H300)
Reproductive toxicity Category 2 - (H361)
Effects on or via lactation Yes - (H362)
Specific target organ toxicity — single exposure Category 1
Label elements
PictogramGHS06 skull
skull
GHS08 silhouete
silhouete
241-917-8 Contains Bupivacaine hydrochloride
Signal word
Danger
Hazard statements
H300 - Fatal if swallowed
H361 - Suspected of damaging fertility or the unborn child
H362 - May cause harm to breast-fed children
H370 - Causes damage to organs
Precautionary Statements - EU (§28, 1272/2008)
P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P263 - Avoid contact during pregnancy and while nursing
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor
P308 + P311 - IF exposed or concerned: Call a POISON CENTER or doctor
2.3. Other hazards
No information available.
This substance does not meet the PBT/vPvB criteria of REACH, annex XIII.
Chemical name Bupivacaine hydrochloride
EU - REACH (1907/2006) - Article 59(1)
- Candidate List of Substances of Very High Concern (SVHC) for Authorisation:-
EU - REACH (1907/2006) - Endocrine Disruptor Assessment List of Substances: -
COMPOSITION/INFORMATION ON INGREDIENTSChemical name Bupivacaine hydrochloride 18010-40-7
Weight-% 100
REACH registrationnumber
EC No 241-917-8
Classification according to Regulation (EC) No. 1272/2008 [CLP] : Acute Tox. 2 (H300) Repr. 2 (H361) Lact. (H362) STOT SE 1 (H370)STOT SE 3 (H336)
Specificconcentrationlimit (SCL) :-
M-Factor M-Factor(long-term) :-
Full text of H- and EUH-phrases: see section 16
Acute Toxicity Estimate
No information available
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.
1907/2006 (REACH), Article 59)
FormulaC18H29ClN2O
Molecular Weight (g/mol)324.89
CAS-No.18010-40-7
FIRST AID MEASURES4.1. Description of first aid measures
General advice Immediate medical attention is required. Show this safety data sheet to the doctor in
attendance.
Inhalation Remove to fresh air. IF exposed or concerned: Get medical advice/attention.
Eye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. If
symptoms persist, call a doctor.
Skin contact Wash off immediately with plenty of water for at least 15 minutes. If symptoms persist, call a
doctor.
Ingestion Get immediate medical advice/attention. Do NOT induce vomiting. Rinse mouth. Never give
anything by mouth to an unconscious person.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms No information available.
4.3. Indication of any immediate medical attention and special treatment needed
Note to doctors Treat symptomatically.
FIRE-FIGHTING MEASURES5.1. Extinguishing media
Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment. Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.
Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the
chemical
No information available.
5.3. Advice for firefighters
Special protective equipment and
precautions for fire-fighters
Firefighters should wear self-contained breathing apparatus and full firefighting turnout
gear. Use personal protection equipment.
ACCIDENTAL RELEASE MEASURES6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions Ensure adequate ventilation. Use personal protective equipment as required. Evacuate
personnel to safe areas.
Other information Refer to protective measures listed in Sections 7 and 8.
For emergency responders Use personal protection recommended in Section 8.
6.2. Environmental precautions
Environmental precautions See Section 12 for additional Ecological Information.
6.3. Methods and material for containment and cleaning up
Methods for containment Prevent further leakage or spillage if safe to do so.
Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal.
Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations.
6.4. Reference to other sections
Reference to other sections See section 8 for more information. See section 13 for more information.
HANDLING AND STORAGE7.1. Precautions for safe handling
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with
skin, eyes or clothing. Do not eat, drink or smoke when using this product. Remove
contaminated clothing and shoes.
General hygiene considerations Wash hands before breaks and immediately after handling the product. Avoid contact with
skin, eyes or clothing. Do not eat, drink or smoke when using this product. Wash hands
before breaks and after work. Wear suitable gloves and eye/face protection.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach
of children. Store locked up. Please refer to the manufacturers certificate for specific
storage and transport temperature conditions. Store only in the original receptacle unless
other advice is given on the CoA.
7.3. Specific end use(s)
Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet.
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1. Control parameters
Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational
exposure limits established by the region specific regulatory bodies.
Biological occupational exposure limits
This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies
Derived No Effect Level (DNEL) No information available.
Predicted No Effect Concentration
(PNEC)
No information available.
8.2. Exposure controls
Personal protective equipment
Eye/face protection Avoid contact with eyes. Wear safety glasses with side shields (or goggles).
Hand protection Wear suitable gloves. The protective gloves to be used must comply with the specifications
Gloves PPE - Glove material Wear protective Viton gloves
Skin and body protection Wear suitable protective clothing.
Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are
exceeded or irritation is experienced, ventilation and evacuation may be required.
General hygiene considerations Wash hands before breaks and immediately after handling the product. Avoid contact with
skin, eyes or clothing. Do not eat, drink or smoke when using this product. Wash hands
before breaks and after work. Wear suitable gloves and eye/face protection.
Environmental exposure controls Do not allow into any sewer, on the ground or into any body of water.
PHYSICAL AND CHEMICAL PROPERTIES9.1. Information on basic physical and chemical properties
Physical state Solid
Appearance Solid
Colour off-white
Odour No data available.
Odour threshold No information available
Property Values Remarks • Method
Melting point / freezing point 250 - 253 °C None known
Boiling point / boiling range No data available None known
Flammability (solid, gas) No data available None known
Flammability Limit in Air None known
Upper flammability or explosive
limits
No data available
Lower flammability or explosive
limits
No data available
Flash point No data available None known
Autoignition temperature No data available None known
Decomposition temperature None known
pH No data available None known
pH (as aqueous solution) No data available No information available
Kinematic viscosity No data available None known
Dynamic viscosity No data available None known
Water solubility No data available None known
Solubility(ies) DMSO, Methanol, slightly soluble
Partition coefficient No data available None known
Vapour pressure No data available None known
Relative density No data available None known
Bulk density No data available
Liquid Density No data available
Relative vapour density No data available None known
Particle characteristics
Particle Size No information available
Particle Size Distribution No information available
9.2. Other information
Molecular weight 324.94
Molecular formula C18H28N2O.ClH
9.2.1. Information with regards to physical hazard classes
Not applicable
9.2.2. Other safety characteristics
No information available
STABILITY AND REACTIVITY10.1. Reactivity
Reactivity No information available.
10.2. Chemical stability
Stability Stable under normal conditions.
Explosion data
Sensitivity to mechanical impact None.
Sensitivity to static discharge None.
10.3. Possibility of hazardous reactions
Possibility of hazardous reactions None under normal processing.
10.4. Conditions to avoid
Conditions to avoid None known based on information supplied.
10.5. Incompatible materials
Incompatible materials None known based on information supplied.
Hazardous decomposition products None known based on information supplied.
TOXICOLOGICAL INFORMATION11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008
Information on likely routes of exposure
Product Information
Inhalation Specific test data for the substance or mixture is not available.
Eye contact Specific test data for the substance or mixture is not available.
Skin contact Specific test data for the substance or mixture is not available.
Ingestion Specific test data for the substance or mixture is not available. Fatal if swallowed. (based on
components).
Symptoms related to the physical, chemical and toxicological characteristics
Symptoms No information available.
Numerical measures of toxicity
Acute toxicity
Component Information
Chemical name Bupivacaine hydrochloride
Oral LD50 18 mg/kg (Rabbit)
Dermal LD50
Inhalation LC50
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation No information available.
Serious eye damage/eye irritation No information available.
Respiratory or skin sensitisation No information available.
Germ cell mutagenicity No information available.
Carcinogenicity No information available.
Reproductive toxicity Contains a known or suspected reproductive toxin. Classification based on data available
for ingredients. May cause harm to breast-fed children. Suspected of damaging fertility or
the unborn child.
STOT - single exposure Based on the classification criteria of the Globally Harmonized System as adopted in the
country or region with which this safety data sheet complies, this product has been
determined to cause systemic target organ toxicity from acute exposure. (STOT SE).
Causes damage to organs if swallowed.
STOT - repeated exposure No information available.
Aspiration hazard No information available.
11.2. Information on other hazards
11.2.1. Endocrine disrupting properties
Endocrine disrupting properties No information available.
11.2.2. Other information
Other adverse effects No information available.
ECOLOGICAL INFORMATION12.1. Toxicity
Ecotoxicity The environmental impact of this product has not been fully investigated.
12.2. Persistence and degradability
Persistence and degradability No information available.
12.3. Bioaccumulative potential
Bioaccumulation No information available.
12.4. Mobility in soil
Mobility in soil No information available.
12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment No information available.
12.6. Endocrine disrupting properties
Endocrine disrupting properties No information available.
12.7. Other adverse effects
No information available.
DISPOSAL CONSIDERATIONS13.1. Waste treatment methods
Waste from residues/unused
products
Dispose of in accordance with local regulations. Dispose of waste in accordance with
environmental legislation.
Contaminated packaging Do not reuse empty containers.
TRANSPORT INFORMATIONIATA
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride), 6.1, II
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions A3, A5
ERG Code 6L
IMDG
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride), 6.1, II
14.5 Marine pollutant NP
14.6 Special precautions for user
Special Provisions 274
EmS-No F-A, S-A No information available
14.7 Maritime transport in bulk
according to IMO instruments
No information available
RID
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride), 6.1, II
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions 274, 614
Classification code T2
ADR
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride), 6.1, II, (D/E)
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions 274, 614
Classification code T2
Tunnel restriction code (D/E)
REGULATORY INFORMATION15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Water hazard class (WGK) strongly hazardous to water (WGK 3)
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work.
Authorisations and/or restrictions on use:
This product does not contain substances subject to authorisation (Regulation (EC) No. 1907/2006 (REACH), Annex XIV) This
product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH), Annex XVII)
DIRECTIVE (EU) 2021/1187 on the marketing and use of explosives precursors
Not applicable
Persistent Organic Pollutants
Not applicable
Dangerous substance category per Seveso Directive (2012/18/EU)
H2 - ACUTE TOXIC
H3 - STOT SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE
Ozone-depleting substances (ODS) regulation (EC) 1005/2009
Not applicable
International Inventories
TSCA Contact supplier for inventory compliance status
DSL/NDSL Contact supplier for inventory compliance status
EINECS/ELINCS Contact supplier for inventory compliance status
ENCS Contact supplier for inventory compliance status
IECSC Contact supplier for inventory compliance status
KECL Contact supplier for inventory compliance status
PICCS Contact supplier for inventory compliance status
AICS Contact supplier for inventory compliance status
Legend:
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
Chemical Safety Report A Chemical Safety Assessment has been carried out for this substance
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!