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17-beta-Estradiol
| Item number | 690093 |
| CAS | 50-28-2 |
| Formula | C18H24O2 |
| Molecular weight | 272,38 g/mol |
| Quantity | 1X250MG |
| storage conditions | 4 °C |
| CoA / MSDS | Retrieve CoA Retrieve MSDS |
Price | Please log in. |
Part of Product groups:
Product Variations:
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 690093 | 1X250MG | Please log in. | |
 | 672995 | 1X100MG | Please log in. | |
 | 683801 | 1X5MG | ||
 | 684914 | 1X10MG | Please log in. | |
D3-17-beta-Estradiol solution |  | 687167 | 1X1ML |
| Safety Data Sheet | according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 04.12.2024 |
| IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING | |
| Product name: | 17-beta-Estradiol |
| Catalog No.: | 690093 |
| Relevant identified uses of the substance or mixture | Identified: Laboratory chemical uses: R&D |
| Uses advised against: | HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com |
| Emergency telephone number | HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours. |
| HAZARDS IDENTIFICATION | 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Carcinogenicity (Category 2), H351 Reproductive toxicity (Category 1A), H360Fd Effects on or via lactation, H362 For the full text of the H-Statements mentioned in this Section, see Section 16. |
| Label elements | |
| Pictogram | GHS08 silhouete silhouete |
| 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H351 Suspected of causing cancer. H360Fd May damage fertility. Suspected of damaging the unborn child. H362 May cause harm to breast-fed children. Precautionary statement(s) P201 Obtain special instructions before use. P260 Do not breathe dusts or mists. P263 Avoid contact during pregnancy and while nursing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements none Reduced Labeling (<= 125 ml) Pictogram Signal word Danger Hazard statement(s) H351 Suspected of causing cancer. H362 May cause harm to breast-fed children. H360Fd May damage fertility. Suspected of damaging the unborn child. Precautionary statement(s) P201 Obtain special instructions before use. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. | |
| COMPOSITION/INFORMATION ON INGREDIENTS | 3.1 Substances Formula : C18H24O2 Molecular weight : 272,39 g/mol CAS-No. : 50-28-2 EC-No. : 200-023-8 Component estradiol CAS-No. : 50-28-2 EC-No. : 200-023-8 Classification Carc. 2; Repr. 1A; Lact. ; Aquatic Chronic 1; H351, H360FD, H362, H410 Concentration <= 100 % For the full text of the H-Statements mentioned in this Section, see Section 16. |
| Formula | C18H24O2 |
| Molecular Weight (g/mol) | 272.38 |
| CAS-No. | 50-28-2 |
| FIRST AID MEASURES | 4.1 Description of first-aid measures General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available |
| FIRE-FIGHTING MEASURES | 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available |
| ACCIDENTAL RELEASE MEASURES | 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13. |
| HANDLING AND STORAGE | 7.1 Precautions for safe handling Advice on safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Advice on safe handling Avoid exposure - obtain special instructions before use. Advice on protection against fire and explosion Provide appropriate exhaust ventilation at places where dust is formed. Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store at Room Temperature. Storage class Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| EXPOSURE CONTROLS/PERSONAL PROTECTION | 8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a fullface particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. |
| PHYSICAL AND CHEMICAL PROPERTIES | 9.1 Information on basic physical and chemical properties a) Appearance Form: powder Color: white b) Odor No data available c) Odor Threshold No data available d) pH No data available e) Melting point/freezing point 176 °C f) Initial boiling point and boiling range No data available g) Flash point No data available h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower flammability or explosive limits No data available k) Vapor pressure No data available l) Vapor density No data available m) Density No data available Relative density No data available n) Water solubility No data available o) Partition coefficient: n-octanol/water No data available p) Autoignition temperature No data available q) Decomposition temperature No data available r) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information No data available |
| STABILITY AND REACTIVITY | 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Strong oxidizing agents 10.6 Hazardous decomposition products In the event of fire: see section 5 |
| TOXICOLOGICAL INFORMATION | 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - male and female - > 5.000 mg/kg Remarks: (ECHA) The value is given in analogy to the following substances: Estradiol valerate Inhalation: No data available Dermal: No data available Skin corrosion/irritation No data available Serious eye damage/eye irritation Eyes - In vitro study Result: No eye irritation - 5 min Remarks: (ECHA) Respiratory or skin sensitization Local lymph node assay (LLNA) - Mouse Result: negative (OECD Test Guideline 429) Germ cell mutagenicity Test Type: Ames test Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: Genotoxicity in vivo Species: Rat Cell type: Liver cells Application Route: Oral Result: negative Carcinogenicity No data available Reproductive toxicity May damage the unborn child. Positive evidence from human epidemiological studies. May damage fertility. Positive evidence from human epidemiological studies. Studies indicating a hazard to babies during the lactation period Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Other dangerous properties can not be excluded. This substance should be handled with particular care. Liver - Irregularities - Based on Human Evidence |
| ECOLOGICAL INFORMATION | 12.1 Toxicity Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 2,48 mg/l - 72 h (OECD Test Guideline 201) 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d Result: 68 % - According to the results of tests of biodegradability this product is not readily biodegradable. (OECD Test Guideline 301B) Remarks: The 10 day time window criterion is not fulfilled. 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects No data available |
| DISPOSAL CONSIDERATIONS | 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. |
| TRANSPORT INFORMATION | 14.1 UN number ADR/RID: - IMDG: - IATA: - 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods 14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: - 14.4 Packaging group ADR/RID: - IMDG: - IATA: - 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user Further information Not classified as dangerous in the meaning of transport regulations. |
| REGULATORY INFORMATION | 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out |
| OTHER INFORMATION | The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only! |