Coumarin

Item number	690687
CAS	91-64-5
Formula	C9H6O2
Molecular weight	146,14 g/mol
Quantity	1X250MG
storage conditions	20 °C
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Coumarin

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Product		Catalog No./ CAS No.	Quantity	Price
Coumarin		690687 91-64-5	1X250MG	Please log in.
D4-Coumarin		676037 185056-83-1	1X10MG	Please log in.

Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	Coumarin
Catalog No.:	690687
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Dermal (Category 3), H311 Skin sensitization (Category 1), H317
Label elements
Pictogram	GHS06 skull skull
	Signal Word Danger Hazard statement(s) H301 + H311 Toxic if swallowed or in contact with skin. H317 May cause an allergic skin reaction. Precautionary statement(s) P261 Avoid breathing dust. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/ doctor if you feel unwell. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : 1,2-Benzopyrone 1-Benzopyran-2-one 2H-Chromen-2-one Formula : C9H6O2 Molecular weight : 146,14 g/mol CAS-No. : 91-64-5 EC-No. : 202-086-7 Component Classification 2H-1-benzopyran-2-one CAS-No. 91-64-5 EC-No. 202-086-7 Acute Tox. 3; Skin Sens. 1; H301, H311, H317
Formula	C9H6O2
Molecular Weight (g/mol)	146.14
CAS-No.	91-64-5
FIRST AID MEASURES	4.1 Description of first-aid measures General advice First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately. In case of eye contact After eye contact: rinse out with plenty of water. Remove contact lenses. If swallowed If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labeling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Water Foam Carbon dioxide (CO2) Dry powder Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Carbon oxides Combustible. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Prevent fire extinguishing water from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. 6.4 Reference to other sections For disposal see section 13.
HANDLING AND STORAGE	7.1 Precautions for safe handling For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. Storage class Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION	8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection protective clothing Respiratory protection required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type P3 The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains.
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Physical state flakes b) Color colorless c) Odor pleasant d) Melting point/freezing point Melting point/range: 68 - 73 °C - lit. e) Initial boiling point and boiling range 298 °C - lit. f) Flammability (solid, gas) The product is not flammable. g) Upper/lower flammability or explosive limits No data available h) Flash point 162 °C - closed cup i) Autoignition temperature No data available j) Decomposition temperature No data available k) pH No data available l) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available m) Water solubility ca.1,9 g/l at 20 °C - US-EPA n) Partition coefficient: n-octanol/water No data available o) Vapor pressure No data available p) Density ca.0,935 kg/m3 at 20 °C Relative density ca.0,935 at 20 °C - OPPTS 830.7300 q) Relative vapor density r) Particle characteristics No data available s) Explosive properties No data available t) Oxidizing properties none 9.2 Other safety information No data available
STABILITY AND REACTIVITY	10.1 Reactivity Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical. The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . 10.3 Possibility of hazardous reactions Violent reactions possible with: Strong oxidizing agents Strong acids strong alkalis 10.4 Conditions to avoid Strong heating. 10.5 Incompatible materials no information available 10.6 Hazardous decomposition products In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - male and female - 293 mg/kg Remarks: (ECHA) Acute toxicity estimate Oral - 293 mg/kg (Calculation method) Inhalation: No data available LD50 Dermal - Rat - 293 mg/kg Remarks: (ECHA) Acute toxicity estimate Dermal - 293 mg/kg (Calculation method) Skin corrosion/irritation Skin - Rabbit Result: No skin irritation - 4 h (Regulation (EC) No. 440/2008, Annex, B.4) Serious eye damage/eye irritation Eyes - Rabbit Result: No eye irritation - 4 Days (US-EPA) Respiratory or skin sensitization Local lymph node assay (LLNA) - Mouse Result: positive (OECD Test Guideline 429) Germ cell mutagenicity Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473 Result: positive Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476 Result: negative Test Type: In vivo micronucleus test Species: Mouse Cell type: Bone marrow Application Route: Oral Method: OECD Test Guideline 474 Result: negative Carcinogenicity This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. Reproductive toxicity No data available Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Repeated dose toxicity - Mouse - male and female - Oral - 13 Weeks - NOAEL (No observed adverse effect level) - > 138,3 mg/kg Remarks: (ECHA) RTECS: GN4200000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Systemic effects: If swallowed Possible symptoms: depressed respiration Drowsiness narcosis Toxic effect on: Liver Kidney Substances which occur in nature Other dangerous properties can not be excluded. Handle in accordance with good industrial hygiene and safety practice.
ECOLOGICAL INFORMATION	12.1 Toxicity Toxicity to daphnia and other aquatic invertebrates Remarks: No data available (2H-1-benzopyran-2-one) Toxicity to bacteria 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d Result: ca.90 % - Readily biodegradable. (OECD Test Guideline 301F) 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. 12.7 Other adverse effects No data available
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods Product See https://www.hpc-standards.com/ for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
TRANSPORT INFORMATION	14.1 UN number ADR/RID: 2811 IMDG: 2811 IATA: 2811 14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (2H-1-benzopyran-2-one) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (2H-1-benzopyran-2-one) IATA: Toxic solid, organic, n.o.s. (2H-1-benzopyran-2-one) 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user Tunnel restriction code : (E) Further information : No data available
REGULATORY INFORMATION	15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. Other regulations Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!

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Coumarin