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Chlorpromazine hydrochloride Solution (Solvent: Acetonitrile)

Item number686133
CAS69-09-0
FormulaC17H20Cl2N2S
Molecular weight355,33 g/mol
Quantity 1X5ML
Concentration100 µg/ml
SolventAcetonitrile
storage conditions4 °C
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Chlorpromazine hydrochloride

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Catalog No./ CAS No.

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Chlorpromazine hydrochloride

Chlorpromazine hydrochloride

677954
69-09-0

1X250MG

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Chlorpromazine hydrochloride solution
Concentration: 100 µg/ml
Solvent: Acetonitrile

Chlorpromazine hydrochloride solution

686133
69-09-0

1X5ML

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D6-Chlorpromazine hydrochloride

D6-Chlorpromazine hydrochloride

679586
1228182-46-4

1X10MG

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D6-Chlorpromazine hydrochloride solution
Concentration: 100 µg/ml
Solvent: Acetonitrile

D6-Chlorpromazine hydrochloride solution

690882
1228182-46-4

1X1ML

On request

Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 23.11.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Chlorpromazine hydrochloride
Catalog No.:686133
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1. Classification of the substance or mixture
Regulation (EC) No 1272/2008
Acute toxicity - Oral Category 3 - (H301)
Acute toxicity - Inhalation (Dusts/Mists) Category 2 - (H330)
Skin corrosion/irritation Category 2 - (H315)
Serious eye damage/eye irritation Category 2 - (H319)
Skin sensitisation Category 1 - (H317)
Reproductive toxicity Category 1B - (H360)
Effects on or via lactation Yes - (H362)
Specific target organ toxicity — single exposure Category 3 - (H336)
Specific target organ toxicity — repeated exposure Category 2 - (H373)
Chronic aquatic toxicity Category 3 - (H412)
Label elements
PictogramGHS06 skull
skull
GHS08 silhouete
silhouete
200-701-3
Contains Chlorpromazine Hydrochloride
Signal word
Danger
Hazard statements
H301 - Toxic if swallowed
H315 - Causes skin irritation
H317 - May cause an allergic skin reaction
H319 - Causes serious eye irritation
H330 - Fatal if inhaled
H336 - May cause drowsiness or dizziness
H360 - May damage fertility or the unborn child
H362 - May cause harm to breast-fed children
H373 - May cause damage to organs through prolonged or repeated exposure
H412 - Harmful to aquatic life with long lasting effects
Precautionary Statements - EU (§28, 1272/2008)
P201 - Obtain special instructions before use
P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P263 - Avoid contact during pregnancy and while nursing
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P310 - Immediately call a POISON CENTER or doctor
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
2.3. Other hazards
No information available.
This substance does not meet the PBT/vPvB criteria of REACH, annex XIII.
COMPOSITION/INFORMATION ON INGREDIENTSChemical name: Chlorpromazine Hydrochloride 69-09-0
Weight-%: 100
REACH registration number: -
EC No: 200-701-3
Classification according to Regulation (EC) No. 1272/2008 [CLP]: Acute Tox. 2 (H330) Acute Tox. 3 (H301) Skin Irrit. 2 (H315) Eye Irrit. 2 (H319) Skin Sens. 1 (H317) Repr. 1B (H360) Lact. (H362) STOT SE 3 (H336) STOT RE 2 (H373) Aquatic Chronic 3(H412)
Specific concentrationlimit (SCL): -
M-Factor: -
M-Factor (long-term): -
Full text of H- and EUH-phrases: see section 16
Acute Toxicity Estimate
If LD50/LC50 data is not available or does not correspond to the classification category, then the appropriate conversion
value from CLP Annex I, Table 3.1.2, is used to calculate the acute toxicity estimate (ATEmix) for classifying a mixture
based on its components
Chemical name: Chlorpromazine Hydrochloride 69-09-0
Oral LD50 mg/kg: 145
Dermal LD50 mg/kg: No data available
Inhalation LC50 - 4 hour - dust/mist - mg/L: No data available
Inhalation LC50 - 4 hour - vapour - mg/L: No data available
Inhalation LC50 - 4hour - gas - ppm : No data available
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.
1907/2006 (REACH), Article 59)
FormulaC17H20Cl2N2S
Molecular Weight (g/mol)355.33
CAS-No.69-09-0
FIRST AID MEASURES4.1. Description of first aid measures
General advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is
required.
Inhalation If breathing has stopped, give artificial respiration. Get medical attention immediately Remove to fresh air. Do not breathe dust. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask
equipped with a one-way valve or other proper respiratory medical device. If breathing is
difficult, (trained personnel should) give oxygen. IF exposed or concerned: Get medical
advice/attention. Get medical attention immediately if symptoms occur.
Eye contact Remove contact lenses, if present and easy to do. Continue rinsing. Keep eye wide open
while rinsing. Do not rub affected area. Get medical attention if irritation develops and
persists. Rinse immediately with plenty of water, also under the eyelids, for at least 15
minutes.
Skin contact May cause an allergic skin reaction. In the case of skin irritation or allergic reactions see a
doctor. Wash off immediately with soap and plenty of water for at least 15 minutes.
Ingestion Do NOT induce vomiting. Rinse mouth. Never give anything by mouth to an unconscious
person. Call a doctor or poison control centre immediately.
Self-protection of the first aider Avoid contact with skin, eyes or clothing. Ensure that medical personnel are aware of the
material(s) involved, take precautions to protect themselves and prevent spread of
contamination. Do not breathe dust. Do not use mouth-to-mouth method if victim ingested
or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped
with a one-way valve or other proper respiratory medical device. Use personal protective
equipment as required. See section 8 for more information.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms Inhalation of high vapour concentrations may cause symptoms like headache, dizziness,
tiredness, nausea and vomiting. Coughing and/ or wheezing. Difficulty in breathing. Itching.
Rashes. Hives. May cause redness and tearing of the eyes. Burning sensation
4.3. Indication of any immediate medical attention and special treatment needed
Note to doctors May cause sensitisation in susceptible persons. Treat symptomatically.
FIRE-FIGHTING MEASURESSuitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.
Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the Product is or contains a sensitiser. May cause sensitisation by skin contact
chemical
5.3. Advice for firefighters
Special protective equipment and
precautions for fire-fighters
Firefighters should wear self-contained breathing apparatus and full firefighting turnout
gear. Use personal protection equipment.
ACCIDENTAL RELEASE MEASURES6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid generation of
dust. Do not breathe dust. Use personal protective equipment as required. Evacuate
personnel to safe areas. Keep people away from and upwind of spill/leak.
Other information Refer to protective measures listed in Sections 7 and 8.
For emergency responders Use personal protection recommended in Section 8.
6.2. Environmental precautions
Environmental precautions Prevent further leakage or spillage if safe to do so. Should not be released into the
environment. Do not allow to enter into soil/subsoil. Prevent product from entering drains.
6.3. Methods and material for containment and cleaning up
Methods for containment Prevent further leakage or spillage if safe to do so.
Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal.
Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations.
6.4. Reference to other sections
Reference to other sections See section 8 for more information. See section 13 for more information.
HANDLING AND STORAGE7.1. Precautions for safe handling
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. In case of
insufficient ventilation, wear suitable respiratory equipment. Avoid breathing vapours or
mists. Avoid contact with skin, eyes or clothing. Handle product only in closed system or
provide appropriate exhaust ventilation. Do not eat, drink or smoke when using this product.
Take off contaminated clothing and wash it before reuse. Remove contaminated clothing
and shoes
General hygiene considerations Do not breathe dust. Take off contaminated clothing and wash it before reuse.
Contaminated work clothing should not be allowed out of the workplace. Regular cleaning
of equipment, work area and clothing is recommended. Wash hands before breaks and
immediately after handling the product. Avoid contact with skin, eyes or clothing. Do not
eat, drink or smoke when using this product. Wash hands before breaks and after work.
Wear suitable gloves and eye/face protection.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach
of children. Please refer to the manufacturers certificate for specific storage and transport
temperature conditions. Store only in the original receptacle unless other advice is given on
the CoA.
7.3. Specific end use(s)
Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet.
EXPOSURE CONTROLS/PERSONAL PROTECTIONExposure Limits
Chemical name: Chlorpromazine Hydrochloride 69-09-0
France: -
Germany: Skin sensitizer
Germany MAK: -
Greece: -
Hungary: -
Biological occupational exposure limits
This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies
Derived No Effect Level (DNEL) No information available.
Predicted No Effect Concentration
(PNEC)
No information available.
8.2. Exposure controls
Personal protective equipment
Eye/face protection If splashes are likely to occur, wear safety glasses with side-shields. Avoid contact with
eyes. Wear safety glasses with side shields (or goggles).
Hand protection Wear suitable gloves. Impervious gloves. The protective gloves to be used must comply
with the specifications of EC Directive 89/686/EEC and the related standard EN374. Wear
protective Viton™ gloves.
Skin and body protection Long sleeved clothing. Wear suitable protective clothing.
Respiratory protection When workers are facing concentrations above the exposure limit they must use
appropriate certified respirators.
General hygiene considerations Do not breathe dust. Take off contaminated clothing and wash it before reuse.
Contaminated work clothing should not be allowed out of the workplace. Regular cleaning
of equipment, work area and clothing is recommended. Wash hands before breaks and
immediately after handling the product. Avoid contact with skin, eyes or clothing. Do not
eat, drink or smoke when using this product. Wash hands before breaks and after work.
Wear suitable gloves and eye/face protection.
Environmental exposure controls Do not allow into any sewer, on the ground or into any body of water.
PHYSICAL AND CHEMICAL PROPERTIES9.1. Information on basic physical and chemical properties
Physical state Solid
Appearance Solid
Colour white
Odour No information available.
Odour threshold No information available
Property Values Remarks • Method
Melting point / freezing point 194 - 199 °C None known
Boiling point / boiling range No data available None known
Flammability (solid, gas) No data available None known
Flammability Limit in Air None known
Upper flammability or explosive
limits
No data available
Lower flammability or explosive
limits
No data available
Flash point No data available None known
Autoignition temperature No data available None known
Decomposition temperature None known
pH No data available None known
pH (as aqueous solution) No data available No information available
Kinematic viscosity No data available None known
Dynamic viscosity No data available None known
Water solubility Soluble in water None known
Solubility(ies) Alcohol
Partition coefficient No data available None known
Vapour pressure No data available None known
Relative density No data available None known
Bulk density No data available
Liquid Density No data available
Relative vapour density No data available None known
Particle characteristics
Particle Size No information available
Particle Size Distribution No information available
9.2. Other information
Molecular weight 355.32
Molecular formula C17 H19 Cl N2 S . HCl
9.2.1. Information with regards to physical hazard classes
Not applicable
9.2.2. Other safety characteristics
No information available
STABILITY AND REACTIVITY10.1. Reactivity
Reactivity No information available.
10.2. Chemical stability
Stability Stable under normal conditions.
Explosion data
Sensitivity to mechanical impact None.
Sensitivity to static discharge None.
10.3. Possibility of hazardous reactions
Possibility of hazardous reactions None under normal processing.
10.4. Conditions to avoid
Conditions to avoid Excessive heat.
10.5. Incompatible materials
Incompatible materials Strong acids. Strong bases. Strong oxidising agents.
Hazardous decomposition products None known based on information supplied.
TOXICOLOGICAL INFORMATION11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008
Information on likely routes of exposure
Product Information
Inhalation Specific test data for the substance or mixture is not available. Fatal if inhaled. (based on
components).
Eye contact Specific test data for the substance or mixture is not available. Causes serious eye irritation.
(based on components). May cause redness, itching, and pain.
Skin contact Specific test data for the substance or mixture is not available. May cause sensitisation by
skin contact. Repeated or prolonged skin contact may cause allergic reactions with
susceptible persons. (based on components). Causes skin irritation.
Ingestion Specific test data for the substance or mixture is not available. Ingestion may cause
gastrointestinal irritation, nausea, vomiting and diarrhoea. Toxic if swallowed. (based on
components).
Symptoms related to the physical, chemical and toxicological characteristics
Symptoms May cause redness and tearing of the eyes. Inhalation of high vapour concentrations may
cause symptoms like headache, dizziness, tiredness, nausea and vomiting. Coughing and/
or wheezing. Difficulty in breathing. Itching. Rashes. Hives. Redness.
Numerical measures of toxicity
Acute toxicity
Component Information
Chemical name: Chlorpromazine Hydrochloride
Oral LD50 = 145 mg/kg ( Rat )
Dermal LD50: -
Inhalation LC50 = 40 mg/m3 ( Rat ) 2 h
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation Classification based on data available for ingredients. Irritating to skin.
Serious eye damage/eye irritation Classification based on data available for ingredients. Causes serious eye irritation.
Respiratory or skin sensitisation May cause sensitisation by skin contact.
Germ cell mutagenicity No information available.
Carcinogenicity No information available.
Reproductive toxicity Contains a known or suspected reproductive toxin. Classification based on data available
for ingredients. May damage fertility or the unborn child. May cause harm to breast-fed
children.
STOT - single exposure May cause drowsiness or dizziness.
STOT - repeated exposure May cause damage to organs through prolonged or repeated exposure.
Aspiration hazard No information available.
11.2. Information on other hazards
11.2.1. Endocrine disrupting properties
Endocrine disrupting properties No information available.
11.2.2. Other information
Other adverse effects No information available.
ECOLOGICAL INFORMATION12.1. Toxicity
Ecotoxicity Harmful to aquatic life with long lasting effects.
12.2. Persistence and degradability
Persistence and degradability No information available.
12.3. Bioaccumulative potential
Bioaccumulation No information available.
12.4. Mobility in soil
Mobility in soil No information available.
12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment The product does not contain any substance(s) classified as PBT or vPvB.
12.6. Endocrine disrupting properties
Endocrine disrupting properties No information available.
12.7. Other adverse effects
No information available.
DISPOSAL CONSIDERATIONS13.1. Waste treatment methods
Waste from residues/unused
products
Dispose of in accordance with local regulations. Dispose of waste in accordance with
environmental legislation.
Contaminated packaging Do not reuse empty containers.
TRANSPORT INFORMATIONIATA
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride), 6.1, II
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions A3, A5
ERG Code 6L
IMDG
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride), 6.1, II
14.5 Marine pollutant NP
14.6 Special precautions for user
Special Provisions 274
EmS-No F-A, S-A No information available
14.7 Maritime transport in bulk
according to IMO instruments
No information available
RID
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride), 6.1, II
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions 274, 614
Classification code T2
ADR
14.1 UN number or ID number UN2811
14.2 UN proper shipping name Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2811, Toxic solid, organic, n.o.s. (Chlorpromazine Hydrochloride), 6.1, II, (D/E)
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions 274, 614
Classification code T2
Tunnel restriction code (D/E)
REGULATORY INFORMATION15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Water hazard class (WGK) strongly hazardous to water (WGK 3)
Poland SDS created according to the following Polish regulation: Act of February 25, 2011
on chemical substances and their mixtures (Journal of Laws of 2018, item 143, as
amended). Regulation (EC) No 1907/2006 of the European Parliament and of the
Council on the Registration, Evaluation, Authorization and Restriction of Chemicals
(REACH), establishing the European Chemicals Agency (EC) as amended. Regulation
(EC) No 1272/2008 of the European Parliament and of the Council of 16 December
2008 on classification, labeling and packaging of substances and mixtures, as
amended. Regulation of the Minister of Health of 10 August 2012 on the criteria and
method of classifying chemical substances and their mixtures (Journal of Laws of
2012, item 1018). Regulation of the Minister of Health of 20 April 2012 on labeling
packaging of hazardous substances and mixtures and some mixtures (Journal of
Laws of 2012, item 445). Regulation of the Minister of Family, Labor and Social Policy
of 12 June 2018 on the maximum allowable concentrations and intensities of factors
harmful to health in the work environment (Journal of Laws of 2018, item 1286).
Announcement of the Minister of Economy, Labor and Social Policy of August 28,
2003 on the publication of the unified text of the Ordinance of the Minister of Labor
and Social Policy on general health and safety at work regulations (Journal of Laws
of 2003, No. 169, item 1650) . Regulation of the Minister of Health of 30 December
2004 on occupational safety and health related to the presence of chemical agents in
the workplace (Journal of Laws of 2005, No. 11, item 86). Act of December 14, 2012
on waste (Journal of Laws of 2013, item 21) Regulation of the Minister of Health of
December 30, 2004 on occupational health and safety related to the presence of
chemical agents in the workplace (Journal U. of 2005, No. 11, item 86). Waste Act of
December 14, 2012 (Journal of Laws of 2013, item 21). Act of 13 June 2013 on the
management of packaging and packaging waste, Journal of Laws 2013, item 888).
Government statement of September 24, 2002 - European Agreement on the
International Carriage of Dangerous Goods by Road (ADR) (Journal of Laws No. 194,
item 1629 and Journal of Laws of 2003, No. 207, item 2013 and 2014).
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work.
Authorisations and/or restrictions on use:
This product does not contain substances subject to authorisation (Regulation (EC) No. 1907/2006 (REACH), Annex XIV) This
product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH), Annex XVII)
DIRECTIVE (EU) 2021/1187 on the marketing and use of explosives precursors
Not applicable
Persistent Organic Pollutants
Not applicable
Dangerous substance category per Seveso Directive (2012/18/EU)
H2 - ACUTE TOXIC
Ozone-depleting substances (ODS) regulation (EC) 1005/2009
Not applicable
International Inventories
TSCA Contact supplier for inventory compliance status
DSL/NDSL Contact supplier for inventory compliance status
EINECS/ELINCS Contact supplier for inventory compliance status
ENCS Contact supplier for inventory compliance status
IECSC Contact supplier for inventory compliance status
KECL Contact supplier for inventory compliance status
PICCS Contact supplier for inventory compliance status
AICS Contact supplier for inventory compliance status
Legend:
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
Chemical Safety Report A Chemical Safety Assessment has been carried out for this substance
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!