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Propylene oxide
| Item number | 682819 |
| CAS | 75-56-9 |
| Formula | C3H6O |
| Molecular weight | 58,08 g/mol |
| Quantity | 1X1000MG |
| storage conditions | 4 °C |
| CoA / MSDS | Retrieve CoA Retrieve MSDS |
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Product Variations:
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 682819 | 1X1000MG | Please log in. |
| Safety Data Sheet | according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 08.09.2024 |
| IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING | |
| Product name: | Propylene oxide |
| Catalog No.: | 682819 |
| Relevant identified uses of the substance or mixture | Identified: Laboratory chemical uses: R&D |
| Uses advised against: | HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com |
| Emergency telephone number | HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours. |
| HAZARDS IDENTIFICATION | 2.1. Classification of the substance or mixture Regulation (EC) No 1272/2008 Acute toxicity - Oral Category 4 - (H302) Acute toxicity - Dermal Category 3 - (H311) Acute toxicity - Inhalation (Dusts/Mists) Category 3 - (H331) Serious eye damage/eye irritation Category 2 - (H319) Germ cell mutagenicity Category 1B - (H340) Carcinogenicity Category 1B - (H350) Specific target organ toxicity — single exposure Category 3 - (H335) Category 3 Respiratory irritation |
| Label elements | |
| Pictogram | flamme flamme GHS06 skull skull GHS08 silhouete silhouete |
| 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal Word Danger Hazard statement(s) H224 Extremely flammable liquid and vapor. H302 Harmful if swallowed. H311 + H331 Toxic in contact with skin or if inhaled. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H340 May cause genetic defects. H350 May cause cancer. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements none Restricted to professional users. Reduced Labeling (<= 125 ml) Pictogram Signal Word Danger Hazard statement(s) H224 Extremely flammable liquid and vapor. H340 May cause genetic defects. H350 May cause cancer. H311 + H331 Toxic in contact with skin or if inhaled. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. | |
| COMPOSITION/INFORMATION ON INGREDIENTS | 3.1 Substances Synonyms : (±)-Methyloxirane 1,2-Epoxypropane Formula : C3H6O Molecular weight : 58,08 g/mol CAS-No. : 75-56-9 EC-No. : 200-879-2 Index-No. : 603-055-00-4 Component propylene oxide Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH) CAS-No. : 75-56-9 EC-No. : 200-879-2 Index-No. : 603-055-00-4 Classification Flam. Liq. 1; Acute Tox. 4; Acute Tox. 3; Eye Irrit. 2; Muta. 1B; Carc. 1B; STOT SE 3; H224, H302, H331, H311, H319, H340, H350, H335 Concentration <= 100 % For the full text of the H-Statements mentioned in this Section, see Section 16. |
| Formula | C3H6O |
| Molecular Weight (g/mol) | 58.08 |
| CAS-No. | 75-56-9 |
| FIRST AID MEASURES | 4.1 Description of first-aid measures General advice First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately. In case of eye contact After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. If swallowed After swallowing: immediately make victim drink water (two glasses at most). Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available |
| FIRE-FIGHTING MEASURES | 5.1 Extinguishing media Suitable extinguishing media Carbon dioxide (CO2) Foam Dry powder Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Carbon oxides Combustible. Pay attention to flashback. Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system. |
| ACCIDENTAL RELEASE MEASURES | 6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. Risk of explosion. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area. 6.4 Reference to other sections For disposal see section 13. |
| HANDLING AND STORAGE | 7.1 Precautions for safe handling Advice on safe handling Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. Advice on protection against fire and explosion Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons. Over time, pressure may increase causing containers to burst Handle and open container with care. Heat sensitive. Cool to 0°C before opening. Storage class Storage class (TRGS 510): 3: Flammable liquids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
| EXPOSURE CONTROLS/PERSONAL PROTECTION | 8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Skin protection This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: butyl-rubber Minimum layer thickness: 0,7 mm Break through time: 30 min Material tested:Butoject® (KCL 898) Body Protection Flame retardant antistatic protective clothing. Respiratory protection required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type AX The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains. Risk of explosion. |
| PHYSICAL AND CHEMICAL PROPERTIES | 9.1 Information on basic physical and chemical properties a) Physical state clear, liquid b) Color colorless c) Odor sweet, ether-like d) Melting point/freezing point Melting point/range: -112 °C - lit. e) Initial boiling point and boiling range 34 °C - lit. f) Flammability (solid, gas) No data available g) Upper/lower flammability or explosive limits Upper explosion limit: 36 - 45 %(V) Lower explosion limit: 1,9 %(V) h) Flash point -38 °C - Equilibrium method - closed cup i) Autoignition temperature > 400 °C at 1.005 - 1.018 hPa - Tested according to Directive 92/69/EEC. j) Decomposition temperature No data available k) pH No data available l) Viscosity Viscosity, kinematic: 0,44 mm2/s at 0 °C - OECD Test Guideline 1140,37 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 0,32 mPa.s at 20 °C m) Water solubility 425 g/l at 20 °C - OECD Test Guideline 105 n) Partition coefficient: n-octanol/water log Pow: 0,03 - Bioaccumulation is not expected. o) Vapor pressure 2.028,5 hPa at 55 °C p) Density 0,83 g/mL at 25 °C - lit. Relative density 0,83 at 20 °C - Regulation (EC) No. 440/2008, Annex, A.3 q) Relative vapor density 2,01 - (Air = 1.0) r) Particle characteristics No data available s) Explosive properties No data available t) Oxidizing properties none 9.2 Other safety information Surface tension 71,5 mN/m at 1,06g/l at 21 °C - Surface tension Relative vapor density 2,01 - (Air = 1.0) |
| STABILITY AND REACTIVITY | 10.1 Reactivity Vapors may form explosive mixture with air. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . 10.3 Possibility of hazardous reactions Risk of ignition or formation of inflammable gases or vapours with: Hydrogen fluoride Oxidizing agents Nitric acid Risk of explosion with: polymerisation initiators Oxygen Exothermic reaction with: Strong oxidizing agents Ammonia halogens alkali hydroxides polymerization alkalines Amines metallic oxides metallic chlorides chlorosulfonic acid Hydrogen chloride gas fuming sulfuric acid aluminium chloride acids 10.4 Conditions to avoid Heat. Warming. 10.5 Incompatible materials rubber, various plastics, Copper 10.6 Hazardous decomposition products In the event of fire: see section 5 |
| TOXICOLOGICAL INFORMATION | 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - male and female - 382 - 587 mg/kg (OECD Test Guideline 401) LC50 Inhalation - Rat - male and female - 4 h - 9,95 mg/l - vapor (OECD Test Guideline 403) LD50 Dermal - Rabbit - 950 mg/kg Remarks: (ECHA) Skin corrosion/irritation Skin - Rabbit Result: No skin irritation - 4 h (OECD Test Guideline 404) Serious eye damage/eye irritation Eyes - Rabbit Result: Severe irritations (Draize Test) Remarks: (RTECS) Respiratory or skin sensitization Split adjuvant test - Guinea pig Result: negative Remarks: (ECHA) Germ cell mutagenicity May cause genetic defects. Test Type: Ames test Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: positive Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test Metabolic activation: without metabolic activation Method: OECD Test Guideline 476 Result: positive Test Type: Mutagenicity (mammal cell test): chromosome aberration. Metabolic activation: without metabolic activation Method: OECD Test Guideline 473 Result: positive Test Type: Mutagenicity (mammal cell test): micronucleus. Species: Rat Cell type: Red blood cells (erythrocytes) Application Route: inhalation (vapor) Method: OECD Test Guideline 474 Result: negative Test Type: Mutagenicity (mammal cell test): chromosome aberration. Species: Rat Application Route: inhalation (vapor) Method: OECD Test Guideline 475 Result: negative Carcinogenicity Presumed to have carcinogenic potential for humans Reproductive toxicity No data available Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation. - Respiratory system Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. RTECS: TZ2975000 Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. |
| ECOLOGICAL INFORMATION | 12.1 Toxicity Toxicity to fish static test LC50 - Oncorhynchus mykiss (rainbow trout) - 52 mg/l - 96 h (US-EPA) Toxicity to daphnia and other aquatic invertebrates static test EC50 - Daphnia magna (Water flea) - 350 mg/l - 48 h (US-EPA) Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 240 mg/l - 96 h (US-EPA) Toxicity to bacteria EC10 - Bacteria - 10 mg/l - 17 h 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d Result: 96 % - Readily biodegradable. (OECD Test Guideline 301C) 12.3 Bioaccumulative potential Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected. 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. 12.7 Other adverse effects Stability in water - 15,7 yr Remarks: reaction with hydroxyl radicals(calculated) - ca.11 d Remarks: Hydrolysis |
| DISPOSAL CONSIDERATIONS | 13.1 Waste treatment methods Product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions. |
| TRANSPORT INFORMATION | 14.1 UN number ADR/RID: 1280 IMDG: 1280 IATA: 1280 14.2 UN proper shipping name ADR/RID: PROPYLENE OXIDE IMDG: PROPYLENE OXIDE IATA: Propylene oxide 14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3 14.4 Packaging group ADR/RID: I IMDG: I IATA: I 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available |
| REGULATORY INFORMATION | 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. Authorisations and/or restrictions on use REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). : propylene oxide REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII) : propylene oxide National legislation Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : ACUTE TOXIC : FLAMMABLE LIQUIDS : Propylene oxide Other regulations Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out |
| OTHER INFORMATION | The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only! |