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4,4'-Difluorobenzophenone

Item number676943
CAS345-92-6
FormulaC13H8F2O
Molecular weight218,20 g/mol
Quantity 1X100MG
storage conditions20 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
4,4'-Difluorobenzophenone

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4,4'-Difluorobenzophenone

4,4'-Difluorobenzophenone

676943
345-92-6

1X100MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 27.12.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:4,4'-Difluorobenzophenone
Catalog No.:676943
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Chronic aquatic toxicity (Category 2), H411 Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn, N Harmful, Dangerous for the
environment
R22, R36/37/38, R51/53
Label elements
PictogramGHS07 exclam
exclam
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
Signal word Warning
Hazard statement(s)
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H411 Toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P261 Avoid breathing dust.
P273 Avoid release to the environment.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Formula : C13H8F2O
Molecular weight : 218,2 g/mol
CAS-No. : 345-92-6
EC-No. : 206-466-3
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Bis(4-fluorophenyl) ketone
CAS-No.
EC-No.
345-92-6
206-466-3
Acute Tox. 4; Skin Irrit. 2; Eye
Irrit. 2; STOT SE 3; Aquatic
Chronic 2; H302, H315, H319,
H335, H411
<= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
Bis(4-fluorophenyl) ketone
CAS-No.
EC-No.
345-92-6
206-466-3
Xn, N, R22 - R36/37/38 -
R51/53
<= 100 %
FormulaC13H8F2O
Molecular Weight (g/mol)218.20
CAS-No.345-92-6
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Hydrogen fluoride
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
6.4 Reference to other sections
For disposal see section 13
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage class (TRGS 510): Non Combustible Solids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands. Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: powder
Colour: white
b) Odour odourless
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing
point
108 °C at ca.1.013 hPa
f) Initial boiling point and
boiling range
296 °C at ca.1.013 hPa
g) Flash point 152 °C - Pensky-Martens closed cup - ASTM D 93
h) Evaporation rate No data available
i) Flammability (solid, gas) The product is not flammable. - Flammability (solids)
j) Upper/lower
flammability or
explosive limits
No data available k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density 1.339,9 kg/m3 at 20 °C
n) Water solubility 0,00876 g/l at 20 °C - OECD Test Guideline 105 - slightly soluble
o) Partition coefficient: noctanol/
water
log Pow: 3,37 at 20 °C
p) Auto-ignition
temperature
597 °C at 1.023,0 hPa
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong reducing agents
10.6 Hazardous decomposition products
Other decomposition products - No data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - 2.000 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - > 5.050 mg/m3
(OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 2.500 mg/kg
(OECD Test Guideline 402)
LD50 Intravenous - Mouse - 56 mg/kg
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitisation
Buehler Test - Guinea pig Result: Does not cause skin sensitisation.
(OECD Test Guideline 406)
Germ cell mutagenicity
Ames test
S. typhimurium
Result: negative
Mouse - male and female
Result: negative
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: DJ0685000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish static test LC50 - Danio rerio (zebra fish) - > 6,5 mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to daphnia and
other aquatic
invertebrates
static test EC50 - Daphnia magna (Water flea) - 3,7 mg/l - 48 h
(OECD Test Guideline 202)
Toxicity to algae static test EC50 - Desmodesmus subspicatus (green algae) - 1,92 mg/l - 72 h
(OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 0 % - Not readily biodegradable.
(OECD Test Guideline 301F)
12.3 Bioaccumulative potential
Bioaccumulation Danio rerio (zebra fish) - 15 d
- 0,2 mg/l
Bioconcentration factor (BCF): 74,4
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher 12.6 Other adverse effects
Toxic to aquatic life with long lasting effects
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 3077 IMDG: 3077 IATA: 3077
14.2 UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Bis(4-fluorophenyl)
ketone)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Bis(4-fluorophenyl)
ketone)
IATA: Environmentally hazardous substance, solid, n.o.s. (Bis(4-fluorophenyl) ketone)
14.3 Transport hazard class(es)
ADR/RID: 9 IMDG: 9 IATA: 9
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
14.6 Special precautions for user
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination
packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids
REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!