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N-Nitroso-N-methyl-4-aminobutyric acid Solution (Solvent: Methanol)

Item number686831
CAS61445-55-4
FormulaC5H10N2O3
Molecular weight146,14 g/mol
Quantity 1X1ML
Concentration100 µg/ml
SolventMethanol
storage conditions4 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
N-Nitroso-N-methyl-4-aminobutyric acid

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N-Nitroso-N-methyl-4-aminobutyric acid solution
Concentration: 100 µg/ml
Solvent: Methanol

N-Nitroso-N-methyl-4-aminobutyric acid solution

686831
61445-55-4

1X1ML

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N-Nitroso-N-methyl-4-aminobutyric acid

N-Nitroso-N-methyl-4-aminobutyric acid

687767
61445-55-4

1X25MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:N-Nitroso-N-methyl-4-aminobutyric acid
Catalog No.:686831
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 3), H311
Specific target organ toxicity - single exposure (Category 1), Eyes, Central nervous system,
H370
For the full text of the H-Statements mentioned in this Section, see Section 16.
Label elements
Pictogramflamme
flamme
GHS06 skull
skull
GHS08 silhouete
silhouete
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Danger
Hazard statement(s)
H225 Highly flammable liquid and vapor.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
H370 Causes damage to organs (Eyes, Central nervous system).
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P233 Keep container tightly closed.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor.
Supplemental Hazard
Statements
none
Reduced Labeling (<= 125 ml)
Pictogram
Signal word Danger
Hazard statement(s)
H370 Causes damage to organs.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
Precautionary statement(s)
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTSMixtures
Synonyms : 4-(Methylnitrosoamino)butanoic acid solution
Component
Methanol CAS-No. 67-56-1 EC-No. 200-659-6 Index-No. 603-001-00-X Registrationnumber 01-2119433307-44- XXXX
Classification
Flam. Liq. 2; Acute Tox. 3; STOT SE 1; H225, H301, H331, H311, H370
Concentration limits: >= 10 %: STOT SE 1, H370; 3 - < 10 %: STOT SE 2, H371;
Concentration
>= 90 - <= 100 %
and
Component
4-[Methyl(nitroso)amino]butanoic acid CAS-No. 61445-55-4 EC-No 845-897-7 *
Classification
Carc. 2; H351
Concentration
>= 0,1 - < 1 %
*A registration number is not available for this substance as the substance or its use are
exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006,
the annual tonnage does not require a registration or the registration is envisaged for a
later registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.

FormulaC5H10N2O3
Molecular Weight (g/mol)146.14
CAS-No.61445-55-4
FIRST AID MEASURES4.1 Description of first-aid measures
General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor
in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately
apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact
lenses.
If swallowed
After swallowing: fresh air. Make victim drink ethanol (e.g. 1 drinking glass of a 40%
alcoholic beverage). Call a doctor immediately (mention methanol ingestion). Only in
exceptional cases, if no medical care is available within one hour, induce vomiting (only in
fully conscious persons) and make victim drink ethanol again (approx. 0.3 ml of a 40%
alcoholic beverage/kg body weight/hour).
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Nitrogen oxides (NOx)
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water
from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary
measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition. Keep locked up or in an area accessible only to qualified or authorized
persons.
Storage stability
Recommended storage temperature
2 - 8 °C
Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
required
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following
standards: DIN EN 143, DIN 14387 and other accompanying standards relating to
the used respiratory protection system.
Recommended Filter type: Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color No data available
c) Odor No data available
d) Melting point/freezing point
e) Initial boiling point and boiling range No data available
f) Flammability (solid, gas) No data available
g) Upper/lower flammability or explosive limits No data available
h) Flash point 9,7 °C
i) Autoignition temperature No data available
j) Decomposition temperature No data available
k) pH No data available
l) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available
m) Water solubility No data available
n) Partition coefficient: n-octanol/water No data available
o) Vapor pressure No data available
p) Density No data available Relative density No data available
q) Relative vapor density No data available
r) Particle characteristics No data available
s) Explosive properties Not classified as explosive.
t) Oxidizing properties none
9.2 Other safety information No data available
STABILITY AND REACTIVITY10.1 Reactivity
Vapors may form explosive mixture with air.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Mixture
Acute toxicity
Acute toxicity estimate Oral - 100,1 mg/kg
(Calculation method)
Acute toxicity estimate Inhalation - 4 h - 3,1 mg/l - vapor(Calculation method)
Acute toxicity estimate Dermal - 300,1 mg/kg
(Calculation method)
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Mixture causes damage to organs. - Eyes, Central nervous system
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components
Methanol
Acute toxicity
Acute toxicity estimate Oral - 100,1 mg/kg
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Symptoms: Nausea, Vomiting
Acute toxicity estimate Inhalation - 4 h - 3,1 mg/l - vapor
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Symptoms: Irritation symptoms in the respiratory tract.
Acute toxicity estimate Dermal - 300,1 mg/kg
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation
Remarks: (ECHA)
Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
Remarks: (ECHA)
Respiratory or skin sensitization
Sensitisation test: - Guinea pig
Result: negative
(OECD Test Guideline 406)
Germ cell mutagenicity
Based on available data the classification criteria are not met.
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Did not show carcinogenic effects in animal experiments.
Reproductive toxicity
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
Causes damage to organs. - Eyes, Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Acute oral toxicity - Nausea, Vomiting
Acute inhalation toxicity - Irritation symptoms in the respiratory tract.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
4-[Methyl(nitroso)amino]butanoic acid
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
Suspected of causing cancer.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
ECOLOGICAL INFORMATION12.1 Toxicity
Mixture
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
No data available
Components
Methanol
Toxicity to fish flow-through test LC50 - Lepomis macrochirus (Bluegill) -
15.400,0 mg/l - 96 h
(US-EPA)
Toxicity to daphnia
and other aquatic
invertebrates
semi-static test EC50 - Daphnia magna (Water flea) - 18.260
mg/l - 96 h
(OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green
algae) - ca. 22.000,0 mg/l - 96 h
(OECD Test Guideline 201)
Toxicity to bacteria static test IC50 - activated sludge - > 1.000 mg/l - 3 h
(OECD Test Guideline 209)
4-[Methyl(nitroso)amino]butanoic acid
No data available
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 1230 IMDG: 1230 IATA: 1230
14.2 UN proper shipping name
ADR/RID: METHANOL, SOLUTION
IMDG: METHANOL, SOLUTION
IATA: Methanol, SOLUTION
14.3 Transport hazard class(es)
ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1)
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
REACH - Restrictions on the manufacture,
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
: methanol
National legislation
Seveso III: Directive 2012/18/EU of the European
Parliament and of the Council on the control of
major-accident hazards involving dangerous
substances.
: ACUTE TOXIC
: FLAMMABLE LIQUIDS
Other regulations
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or
stricter national regulations where applicable.
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!