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1,3-Bis(1-isocyanato-1-methylethyl)benzene

Item number685717
CAS2778-42-9
FormulaC14H16N2O2
Molecular weight244,29 g/mol
Quantity 1X250MG
storage conditions4 °C
CoA / MSDSRetrieve CoA
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1,3-Bis(1-isocyanato-1-methylethyl)benzene

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1,3-Bis(1-isocyanato-1-methylethyl)benzene

1,3-Bis(1-isocyanato-1-methylethyl)benzene

685717
2778-42-9

1X250MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 27.12.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:1,3-Bis(1-isocyanato-1-methylethyl)benzene
Catalog No.:685717
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Inhalation (Category 1), H330
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Skin sensitisation (Category 1), H317
Specific target organ toxicity - repeated exposure, Inhalation (Category 1), Lungs, H372
Short-term (acute) aquatic hazard (Category 1), H400
Long-term (chronic) aquatic hazard (Category 1), H410
Label elements
PictogramGHS06 skull
skull
GHS08 silhouete
silhouete
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Danger
Hazard statement(s)
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H330 Fatal if inhaled.
H372 Causes damage to organs (Lungs) through prolonged or
repeated exposure if inhaled.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P273 Avoid release to the environment.
P280 Wear protective gloves.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P314 Get medical advice/ attention if you feel unwell.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
Lachrymator.
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Synonyms : α,α,α′,α′-Tetramethyl-1,3-xylylene diisocyanate
Formula : C14H16N2O2
Molecular weight : 244,29 g/mol
CAS-No. : 2778-42-9
EC-No. : 220-474-4
Component Classification Concentration
1,3-Bis(1-isocyanato-1-methylethyl)benzene
Acute Tox. 1; Skin Irrit. 2;
Eye Irrit. 2; Skin Sens. 1;
STOT RE 1; Aquatic Acute
1; Aquatic Chronic 1;
H330, H315, H319, H317,
H372, H400, H410
M-Factor - Aquatic Acute:
<= 100 % 1
FormulaC14H16N2O2
Molecular Weight (g/mol)244.29
CAS-No.2778-42-9
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult
a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas.
For personal protection see section 8. 6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in
suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent
leakage.
Moisture sensitive.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: colourless
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting
point/freezing point
4 °C at 101,3 hPa - OECD Test Guideline 102
f) Initial boiling point
and boiling range
106 °C at 1,2 hPa - lit.
g) Flash point 168 °C - closed cup - ASTM D 56
h) Evaporation rate No data available
i) Flammability (solid,
gas)
No data available
j) Upper/lower
flammability or
explosive limits
No data available
k) Vapour pressure 0,386 hPa at 25 °C
l) Vapour density No data available
m) Relative density 1,06 g/cm3 at 25 °C n) Water solubility No data available
o) Partition coefficient:
n-octanol/water
No data available
p) Auto-ignition
temperature
498 °C
at 101,3 hPa
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Surface tension 38,6 mN/m at 20 °C
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Avoid moisture.
10.5 Incompatible materials
acids, Peroxides, Alcohols, Amines, Bases
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen
oxides (NOx)
Other decomposition products - No data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 5.337 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - female - 4 h - 0,027 mg/l
(OECD Test Guideline 403)
LD50 Dermal - Rabbit - > 2.000 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Moderate skin Irritation (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation
(OECD Test Guideline 405)
Respiratory or skin sensitisation
Buehler Test - Guinea pig
May cause allergic skin reaction.
Germ cell mutagenicity
in vitro assay
S. typhimurium
Result: negative
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
Inhalation - Causes damage to organs through prolonged or repeated exposure. - Lungs
Aspiration hazard
No data available
Additional Information
RTECS: CY8480000
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea,
Vomiting, To the best of our knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish static test LC50 - Pimephales promelas (fathead minnow) - 0,67 mg/l
- 96 h
Toxicity to daphnia
and other aquatic
invertebrates
static test LC50 - Daphnia magna (Water flea) - 5,2 mg/l - 48 h
(OECD Test Guideline 202)
Toxicity to algae static test EC50 - Pseudokirchneriella subcapitata (green algae) - 6,9
mg/l - 72 h
(OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability Result: 13,7 % - According to the results of tests of biodegradability this product is not readily biodegradable.
(Closed Bottle test)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Very toxic to aquatic life with long lasting effects.
No data available
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 3382 IMDG: 3382 IATA: 3382
14.2 UN proper shipping name
ADR/RID: TOXIC BY INHALATION LIQUID, N.O.S. (1,3-Bis(1-isocyanato-1-
methylethyl)benzene)
IMDG: TOXIC BY INHALATION LIQUID, N.O.S. (1,3-Bis(1-isocyanato-1-
methylethyl)benzene)
IATA: Toxic by inhalation liquid, n.o.s. (1,3-Bis(1-isocyanato-1-methylethyl)benzene)
Passenger Aircraft: Not permitted for transport
Cargo Aircraft: Not permitted for transport
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: I IMDG: I IATA: -
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
14.6 Special precautions for user
No data available
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
REACH - Restrictions on the manufacture,
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
:
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!