gamma-Butyrolactone

Item number	687537
CAS	96-48-0
Formula	C4H6O2
Molecular weight	86,09 g/mol
Quantity	1X1G
storage conditions	20 °C
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gamma-Butyrolactone		687537 96-48-0	1X1G	Please log in.

Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	gamma-Butyrolactone
Catalog No.:	687537
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Serious eye damage (Category 1), H318 Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
Label elements
Pictogram	GHS05 acid acid GHS07 exclam exclam
	2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal word Danger Hazard statement(s) H302 Harmful if swallowed. H318 Causes serious eye damage. H336 May cause drowsiness or dizziness. Precautionary statement(s) P280 Wear eye protection/ face protection. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth. P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Formula : C4H6O2 Molecular weight : 86,09 g/mol CAS-No. : 96-48-0 EC-No. : 202-509-5 Component Classification Concentration γ-Butyrolactone Acute Tox. 4; Eye Dam. 1; STOT SE 3; H302, H318, H336 <= 100 %
Formula	C4H6O2
Molecular Weight (g/mol)	86.09
CAS-No.	96-48-0
FIRST AID MEASURES	4.1 Description of first-aid measures General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information No data available
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13
HANDLING AND STORAGE	7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place. Recommended storage temperature 2 - 8 °C Hygroscopic. 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Appearance Form: liquid, clear Color: colorless b) Odor unpleasant c) Odor Threshold No data available d) pH 4 - 5 at 100 g/l at 20 °C e) Melting Melting point: -45 °C point/freezing point f) Initial boiling point and boiling range 204,6 °C at 1.013 hPa g) Flash point 98 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower flammability or explosive limits Upper explosion limit: 16 %(V) Lower explosion limit: 1,4 %(V) k) Vapor pressure ca.0,34 hPa at 20 °C - (calculated) 3 hPa at ca.52 °C - Tested according to Directive 92/69/EEC. l) Vapor density 2,97 - (Air = 1.0) m) Relative density 1,13 g/cm3 at 20 °C - DIN 51757 n) Water solubility 1.000 g/l at 20 °C - OECD Test Guideline 105 - miscible in all proportions o) Partition coefficient: n-octanol/water log Pow: -0,566 at 25 °C - OECD Test Guideline 107 - Bioaccumulation is not expected. p) Autoignition temperature 435 °C at 1.013,25 hPa - DIN 51794 q) Decomposition temperature No data available r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Relative vapor density 2,97 - (Air = 1.0)
STABILITY AND REACTIVITY	10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid No data available 10.5 Incompatible materials Strong acids, Strong bases, Strong oxidizing agents, Strong reducing agents, Zinc, Plastics 10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - male and female - 1.582 mg/kg (OECD Test Guideline 401) LC50 Inhalation - Rat - male and female - 4 h - > 5,1 mg/l (OECD Test Guideline 403) LD50 Dermal - Guinea pig - > 5.000 mg/kg Remarks: (RTECS) Skin corrosion/irritation Skin - Rabbit Result: No skin irritation - 20 h Remarks: (ECHA) Serious eye damage/eye irritation Eyes - Rabbit Result: Irreversible effects on the eye (OECD Test Guideline 405) Respiratory or skin sensitization Local lymph node assay (LLNA) - Mouse Result: negative (OECD Test Guideline 429) Germ cell mutagenicity OECD Test Guideline 477 Drosophila melanogaster - male Result: negative Carcinogenicity This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available Specific target organ toxicity - single exposure May cause drowsiness or dizziness. Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available Additional Information Repeated dose toxicity - Rat - male - Oral - 90 d - NOAEL (No observed adverse effect level) - 225 mg/kg (ECHA) RTECS: LU3500000 an anesthetic effect on the central nervous system characterized by a loss of sensation., Preliminary excitement is the initial effect followed by relaxation, stupor, or sleep., Nausea, Dizziness, Headache To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Systemic effects: Drowsiness, depressed respiration, Tiredness, Headache After absorption of large quantities: cardiovascular disorders, narcosis Other dangerous properties can not be excluded. Handle in accordance with good industrial hygiene and safety practice. Liver - Irregularities - Based on Human Evidence
ECOLOGICAL INFORMATION	12.1 Toxicity Toxicity to fish static test LC50 - Lepomis macrochirus (Bluegill sunfish) - 56 mg/l - 96 h (OECD Test Guideline 203) Toxicity to daphnia and other aquatic invertebrates static test EC50 - Daphnia magna (Water flea) - > 500 mg/l - 48 h (Directive 67/548/EEC, Annex V, C.2.) Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 1.000 mg/l - 72 h (DIN 38412) Toxicity to bacteria static test IC50 - Tetrahymena pyriformis - 4.518 mg/l - 40 h Remarks: (ECHA) 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 14 d Result: 95 % - Readily biodegradable. (OECD Test Guideline 301C) Biochemical Oxygen Demand (BOD) 1.160 mg/g 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects Harmful to aquatic life. Additional ecological information Biological effects: Endangers drinking-water supplies if allowed to enter soil and/or waters in large quantities Discharge into the environment must be avoided. Adsorbed organic bound halogens (AOX) Remarks: Product does not contain any organic halogens
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. Contaminated packaging Dispose of as unused product
TRANSPORT INFORMATION	14.1 UN number ADR/RID: - IMDG: - IATA: - 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods 14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: - 14.4 Packaging group ADR/RID: - IMDG: - IATA: - 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user Further information Not classified as dangerous in the meaning of transport regulations
REGULATORY INFORMATION	15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, preparations and articles (Annex XVII) 15.2 Chemical Safety Assessment For this product a chemical safety assessment was not carried out
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!

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gamma-Butyrolactone