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Retinol

Item number677602
CAS68-26-8
FormulaC20H30O
Molecular weight286,45 g/mol
Quantity 1X50MG
storage conditions-20 °C
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Retinol

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Retinol

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677602
68-26-8

1X50MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Retinol
Catalog No.:677602
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Eye irritation
(
Category 2
),
H319
Skin sensitisation
(
Category 1
),
H317
Reproductive toxicity
(
Category 1B
),
H360
Chronic aquatic toxicity
(
Category 4
),
H413
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn
Harmful
R22, R38
Label elements
PictogramGHS07 exclam
exclam
GHS08 silhouete
silhouete
2.2
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word
Danger
Hazard statement(s)
H317
May cause an allergic skin reaction.
H319
Causes serious eye Irritation Sigma
-
R7632
Page
2
of
8
H360
May damage fertility or
the unborn child.
H413
May cause long lasting harmful effects to aquatic life.
Precautionary statement(s)
P201
Obtain special instructions before use.
P280
Wear protective gloves.
P305 + P351 + P338
IF IN EYES: Rinse cautio
usly with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P308 + P313
IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Statements
none
Restricted to professional users.
2.3
Other hazards
-
none
COMPOSITION/INFORMATION ON INGREDIENTS3.1
Substances
Synonyms
:
Axerophthol
Vitamin
A1
Vitamin
A alcohol
all
-
trans
-
3,7
-
Dimethyl
-
9
-
(2,6,6
-
trimethyl
-
1
-
cyclohexen
-
1
-
yl)
-
2,4,6,8
-
nonatetraen
-
1
-
ol
Vitamin
A
Formula
:
C
20
H
30
O
Molecular Weight
:
286,45 g/mol
CAS
-
No.
:
68
-
26
-
8
EC
-
No.
:
200
-
683
-
7
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component
Classification
Concentration
Retinol
CAS
-
No.
EC
-
No.
68
-
26
-
8
200
-
683
-
7
Eye Irrit.
2
;
Skin Sens.
1
;
Repr.
1B
;
Aquatic Chronic
4
;
H317, H319, H360, H413
<= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component
Classification
Concentration
Retinol
CAS
-
No.
EC
-
No.
68
-
26
-
8
200
-
683
-
7
T
,
R38
-
R43
-
R61
<= 100 %
FormulaC20H30O
Molecular Weight (g/mol)286.45
CAS-No.68-26-8
FIRST AID MEASURES4.1
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If b
reathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution. If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2
Most important symptoms and effects, both acute and delayed
The most important known symptoms and
effects are described in the labelling (see section 2.2) and/or in
section 11
4.3
Indication of any immediate medical attention and special treatment needed
no data available
FIRE-FIGHTING MEASURES5.1
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol
-
resistant foam, dry chemical or carbon dioxide.
5.2
Special hazards arising from the substance or mixture
Carbon oxides
5.3
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4
Further information
no data available
ACCIDENTAL RELEASE MEASURES6.1
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
6.2
Environmental precautions
Do not let product enter drains.
6.3
Meth
ods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
6.4
Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2
Conditions for safe storage, including any incompatibilities
Store in cool place.
Keep container tightly closed in a dry and well
-
ventilated place.
Recommended storage temperature:
-
20 °C
Air and moisture sensitive.
Store under nitrogen.
7.3
Specific end use(s)
Apart from the us
es mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1
Control parameters
Components with workplace control parameters
8.2
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side
-
shields conforming to EN1
66 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touch
ing glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands. Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be se
lected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/
P99 (US) or type ABEK
-
P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains
PHYSICAL AND CHEMICAL PROPERTIES9.1
Information on basic physi
cal and chemical properties
a)
Appearance
Form
:
crystalline
b)
Odour
no data available c)
Odour Threshold
no data available
d)
pH
no data available
e)
Melting point/freezing
point
Melting point/range
:
61
-
63 °C
f)
Initial boiling point and
boiling range
no data available
g)
Flash point
no data available
h)
Evapouration rate
no data available
i)
Flammability (solid, gas)
no data available
j)
Upper/lower
flammability or
explosive limits
no data available
k)
Vapour pressure
no data available
l)
Vapour density
no data available
m)
Relative density
no data available
n)
Water solubility
no data available
o)
Partition coefficient: n
-
octanol/water
no data available
p)
Auto
-
ignition
temperature
no data available
q)
Decomposition
temperature
no data available
r)
Viscosity
no data available
s)
Explosive properties
no data available
t)
Oxidizing properties
no data available
9.2
Other safety information
no data available
STABILITY AND REACTIVITY10.1
Reactivity
no data available
10.2
Chemical stability
Stable under recommended storage conditions.
10.3
Possibility of hazardous reactions
no data available
10.4
Conditions to avoid
no data available
10.5
Incompatible materials
Oxidizing agents
10.6
Hazardous decomposition products
Other decomposition products
-
no data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes
-
rabbit
Result
:
Irritating to eyes.
-
24 h
(
OECD Test Guideline 405
)
Respiratory or skin sensitisation
in vivo assay
-
guinea pig
Result
:
May cause sensitisation by skin contact.
(
OECD Test Guideline 406
)
Germ cell mutagenicity
Ames test
S. typhimurium
Result
:
negative
Mutagenicity (micronucleus test)
mouse
-
male
Result
:
negative
Carcinogenicity
IARC:
No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available Specific target organ toxicity
-
single exposure
no data available
Specific target organ toxicity
-
repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS
:
VH6750000
Congenital abnormalities may occur after exposure to high concentrations during pregnancy.,
hypervitaminosis A, yellow pigmentation, Irritability, loss of appetite, Gastrointestinal disturbance,
Repeated exposure may cause skin dryness or cracking., Acute
vitamin A intoxication may occur with
exposure to high concentrations., sedation, Headache, exfoliative lesions
ECOLOGICAL INFORMATION12.1
Toxicity
Toxicity to fish
static test
LC50
-
Leuciscus idus (Golden orfe)
-
> 10.000 mg/l
-
96 h
(
DIN 38412
)
Toxicity to daphnia and
other aquatic
invertebrates
static test
EC50
-
Daphnia magna (Water flea)
-
> 100 mg/l
-
48 h
(
OECD Test Guideline 202
)
Toxicity to bacteria
Respiration inhibition
EC50
-
Sludge Treatment
-
> 1.000 mg/l
-
180 min
(
OECD Test Guideline 209
) 12.2
Persistence and degradability
no data available
12.3
Bioaccumulative potential
no data available
12.4
Mobility in soil
no data available
12.5
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6
Other adverse effects
no data available
DISPOSAL CONSIDERATIONS13.1
Waste treatment methods
Product
Offer surplus and non
-
recyclable solutions to a licensed disposal company.
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused pr
oduct.
TRANSPORT INFORMATION14.1
UN number
ADR/RID
:
-
IMDG
:
-
IATA:
-
14.2
UN proper shipping name
ADR/RID
:
Not dangerous goods
IMDG
:
Not dangerous goods
IATA:
Not dangerous goods
14.3
Transport hazard class(es)
ADR/RID
:
-
IMDG
:
-
IATA:
-
14.4
Packaging group
ADR/RID
:
-
IMDG
:
-
IATA:
-
14.5
Environmental hazards
ADR/RID
:
no
IMDG
Marine pollutant
:
no
IATA:
no
14.6
Special precautions for user
no data available
REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
15.2
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!