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o-Toluidine

Item number676654
CAS95-53-4
FormulaC7H9N
Molecular weight107,15 g/mol
Quantity 1X1ML
storage conditions20 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
o-Toluidine

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o-Toluidine

o-Toluidine

676654
95-53-4

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o-Toluidine solution
Concentration: 100 µg/ml
Solvent: Acetonitrile

o-Toluidine solution

679892
95-53-4

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 15.01.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:o-Toluidine
Catalog No.:676654
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Carcinogenicity (Category 1B), H350
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Oral (Category 3), H301
Eye irritation (Category 2), H319
Acute aquatic toxicity (Category 1), H400
Label elements
PictogramGHS06 skull
skull
GHS08 silhouete
silhouete
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Danger
Hazard statement(s)
H301 Toxic if swallowed.
H319 Causes serious eye irritation
H331 Toxic if inhaled.
H350 May cause cancer.
H400 Very toxic to aquatic life.
Precautionary statement(s)
P201 Obtain special instructions before use.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 Avoid release to the environment.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P311 Call a POISON CENTER /doctor.
Supplemental Hazard
Statements
none
Restricted to professional users.
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
o-Toluidine Included in the Candidate List of Substances of Very High Concern (SVHC) according to
Regulation (EC) No. 1907/2006 (REACH)
EC-No. : 202-429-0
Index-No. : 612-091-00-X
Classification: Acute Tox. 3; Eye Irrit. 2; Carc.
1B; Aquatic Acute 1; H331,
H301, H319, H350, H400
M-Factor - Aquatic Acute: 10
Concentration <= 100 %
FormulaC7H9N
Molecular Weight (g/mol)107.15
CAS-No.95-53-4
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13). Keep in suitable, closed
containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation
of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Light sensitive. Store under inert gas. Air sensitive.
Storage class (TRGS 510): 6.1B: Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous
materials
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
tested and approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator.
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: clear, liquidColour: light yellow
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing
point
Melting point/range: -28 °C
f) Initial boiling point and
boiling range
199 - 200 °C at 1013 hPa
89 - 90 °C at 15 hPa
g) Flash point 85 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower
flammability or
explosive limits
Lower explosion limit: 1,5 %(V)
k) Vapour pressure 0,88 hPa at 38 °C
0,35 hPa at 25 °C
l) Vapour density 3,7 - (Air = 1.0)
m) Relative density 0,998 g/cm3
n) Water solubility slightly soluble
o) Partition coefficient: noctanol/
water
log Pow: 1,32
p) Auto-ignition
temperature
No data available
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Relative vapour density 3,7 - (Air = 1.0)
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Strong oxidizing agents, Strong acids
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)
Other decomposition products - No data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 670 mg/kg
Remarks: Blood:Normocytic anemia. Blood:Pigmented or nucleated red bIood cells.
Blood:Methemoglobinemia-Carboxyhemoglobin.
LC50 Inhalation - Rat - 4 h - 862 ppm
Remarks: Behavioral:Somnolence (general depressed activity). Behavioral:Tremor. Cyanosis
LD50 Dermal - Rabbit - 3.244 mg/kg
Skin corrosion/irritation
Skin - Rabbit
Result: Mild skin irritation - 24 h
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Severe eye irritation - 24 h
Respiratory or skin sensitisation
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
This product is or contains a component that has been reported to be probably carcinogenic based on its
IARC, OSHA, ACGIH, NTP, or EPA classification. Found positive for carcinogenicity in EPA Genetox
program.
Possible human carcinogen
IARC: 1 - Group 1: Carcinogenic to humans (o-Toluidine)
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: XU2975000
Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes
cyanosis. Onset may be delayed 2 to 4 hours or longer., To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly investigated.
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish LC0 - Leuciscus idus melanotus - 30 mg/l - 48,0 h(o-Toluidine)
Toxicity to daphnia and
other aquatic
invertebrates
EC50 - Daphnia magna (Water flea) - 0,31 - 0,86 mg/l - 48 h(o-Toluidine)
Toxicity to algae EC50 - Desmodesmus subspicatus (green algae) - 3,9 mg/l - 72 h(o-Toluidine)
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
Bioaccumulation Cyprinodontidae - 48 h
- 450 mg/l(o-Toluidine)
Bioconcentration factor (BCF): 2,2
12.4 Mobility in soil
No data available(o-Toluidine)
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects
Very toxic to aquatic life.
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
This combustible material may be burned in a chemical incinerator equipped with an afterburner and
scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 1708 IMDG: 1708 IATA: 1708
14.2 UN proper shipping name
ADR/RID: TOLUIDINES, LIQUID
IMDG: TOLUIDINES, LIQUID
IATA: Toluidines, liquid
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: yes IATA: no
14.6 Special precautions for user
No data available
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Authorisations and/or restrictions on use
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!